Unit:
Κατεύθυνση Επείγουσα ΝοσηλευτικήLibrary of the School of Health Sciences
Author:
Manolopoulou Aggeliki
Supervisors info:
Καλεμικεράκης Ιωάννης, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΠΑΔΑ
Καλογιάννη Αντωνία, Αναπληρώτρια Καθηγήτρια, Τμήμα Νοσηλευτικής, ΠΑΔΑ
Τουλιά Γεωργία, Αναπληρώτρια Καθηγήτρια, Τμήμα Νοσηλευτικής, ΠΑΔΑ
Original Title:
Ποσοστά επιτυχίας της ενδοφλέβιας θρομβόλυσης σε ασθενείς με ισχαιμικό Α.Ε.Ε.
Translated title:
Success rate of intravenous thrombolysis in patients with ischemic stroke
Summary:
Introduction: Acute ischemic stroke is one of the main causes of mortality and morbidity worldwide. Until recently, the treatment of patients with acute stroke was characterized by therapeutic passivity. Today, however, this treatment has changed radically thanks to the understanding of the underlying pathophysiological mechanisms and the new therapeutic possibilities that have emerged.
Purpose: The purpose of this systematic review is to investigate the success rate of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) alteplase in patients with acute ischemic stroke.
Method: A systematic review of studies from the last decade (2012-2022) was performed and 15 studies were selected.
Results & Conclusions: The present systematic review provides some evidence based on long- term outcomes of patients with acute ischemic stroke treated with intravenous (IV) rt-PA. It indicates the long-term clinical benefits of IV rt-PA therapy in patient survival and functional recovery. However, there was no statistically significant evidence that IV rt-PA treatment can reduce hospital readmission rates.
Main subject category:
Health Sciences
Keywords:
Ischemic stroke, Thrombolysis, RtPA, Alteplase, effectiveness
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Manolopoulou_Aggeliki_MSc.pdf
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