Unit:
Κατεύθυνση Γενική και Εξειδικευμένη Παιδιατρική: Κλινική Πράξη και ΈρευναLibrary of the School of Health Sciences
Author:
Ketsekioulafis Ioannis
Supervisors info:
Δέσποινα Μπριάνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ευαγγελία Χαρμανδάρη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Μίχος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διαγνωστικοί και προγνωστικοί βιοδείκτες σε νεογνά με περιγεννητικό στρες
Translated title:
Diagnostic and prognostic biomarkers in neonates with perinatal stress
Summary:
Introduction: Perinatal stress is attributed to various stressful stimuli acting from the 22nd week of gestation until the 7th day of extrauterine life, and is associated with increased morbidity/mortality in newborns, as well as with long-term complications in chlildren’s health and development. Therefore, early and valid diagnosis of perinatal stress is necessary in order to avoid its short- and long-term complications. This can be accomplished by determination of structurally and circadian stable molecules, which can serve as perinatal stress biomarkers.
Methodology: A systematic review of the literature was conducted based on PRISMA guidelines and specific investigator-defined criteria. The final selected studies were qualitatively assessed using the Joanna Briggs Institute tools.
Results-Conclusions: Despite the small number of studies that met the research criteria, a sufficient number of compounds are demonstrated as potential biomarkers, useful for the diagnosis of perinatal stress before and after birth with the main representatives being the markers of oxidative stress malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostanes. Further research is needed, so that safer conclusions can be drawn for the use of the above compounds, but also for the identification of new compounds that could possibly serve as biomarkers of perinatal stress.
Main subject category:
Health Sciences
Keywords:
Perinatal, Neonatology, Oxidative stress, Sepsis, Biomarkers
