Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Tsiourantani Foteini
Dissertation committee:
Ευάγγελος Τέρπος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαριάννα Πολίτου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Φλώρα Ζαγουρή, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αργυρή Γιαλεράκη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Γαβριατοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Βασιλειάδης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Θεόδωρος Πιτταράς, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Διαταραχές της αιμόστασης σε ασθενείς που υποβάλλονται σε στεφανιογραφία
Translated title:
Hemostasis disorders in patients submitted to coronary angiography
Summary:
Coronary angiography is a non-surgical, transcutaneous technique that is used for the diagnosis and therapeutic management of obstructive coronary artery disease. It is primarily indicated in acute coronary syndrome, which includes the ST- segment elevation myocardial infarction, the non ST- segment elevation myocardial infarction (NSTEMI) and unstable angina.
The laboratory detection and measurement of factors that contribute to coagulation mechanisms in endothelial dysfunction in patients with coronary heart disease may lead to important conclusions in regard to the contribution of endothelial function to atherosclerotic lesions of coronary arteries.
The purpose of this study is to examine the coagulation disorders and the role of endothelial dysfunction in patients that will undergo coronary angiography. The patients were categorized in three groups: 1) patients with NSTEMI 2) patients with unstable angina and 3) patients with angina pectoris and positive stress test (control group).
Blood samples were collected from each patient in order to determine complete blood count, biochemistry panel, lipidemic profile, hs- CRP and biomarkers of myocardial infarction (troponin I, CK-MB). Furthermore, the measurement of von Willebrand factor (vWF) activity, metalloprotease ADAMTS13 activity, thrombomodulin and myeloperoxidase as markers of endothelial injury and as factors of immunothrombosis was achieved by the use of ELISA and functional coagulation tests.
The main purpose of this study is to add more data to the current medical literature concerning the role of coagulation disorders, endothelial damage and immunothrombosis in patients undergoing coronary angiography and the correlation of these factors with the findings of the angiographic procedure and the subsequent angioplasty. In addition, the comparison of the markers of endothelial injury for each factor of cardiovascular risk of the patients was achieved. The risk factors that were separately studied were smoking, diabetes mellitus, dyslipidemia, arterial hypertension, peripheral arterial disease, chronic renal disease and the family history of coronary artery disease.
Main subject category:
Health Sciences
Keywords:
Coronary artery disease, Endothelial dysfunction, Hemostasis disorders, Thromboinflammation, Immunothrombosis
Number of references:
474
