Κατεύθυνση Ιατρική Φυσική-Ακτινοφυσική
Library of the School of Health Sciences

2024-05-17

2024

Andreou Sotiria

Εμμανουήλ Παπαναστασίου, Αναπληρωτής Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ
Ιωάννης Ιακώβου, Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ
Αναστάσιος Σιούντας, Ομότιμος Καθηγητής, Τμήμα Ιατρικής, ΑΠΘ

Σύγκριση ποσοτικών δεδομένων από απεικόνιση PET/CT με 18F-PSMA-1007 και 18F-Choline σε ασθενείς με καρκίνο του προστάτη

Greek

Comparison between quantitative parameters from 18F-PSMA-1007 and 18F-Choline PET/CT imaging in prostate cancer patients

In this diploma thesis we compared the morphological and quantitative features of 18F-PSMA-1007 (PSMA) and 18F-Choline (FCH) PET/CT in prostate cancer (PCa) patients (pts) with biochemical recurrence (BCR) enrolled in the BIO-CT-001 trial, building upon recent findings from phase III trials demonstrating the superiority of 18F-PSMA-1007 in detecting BCR. One hundred six pts with BCR, who had undergone primary definitive treatment for PCa, were enrolled in this study. All pts underwent one PSMA and one FCH PET/CT examination in randomized order within 10 days. Pathology, PSA level, PSA doubling time and PSA Velocity were analyzed. Using LifeX software (www.lifexsoft.org) SUVmax, SUVmean, PSMA and Choline total volume (PSMA-TV/FCH-TV) and total lesion PSMA and Choline (TL-PSMA/TL-FCH) for all identified metastatic lesions in both tracers were calculated.
A total of 286 lesions were identified. 140 (49%) were lymph node metastases, 118 (41.2%) were bone metastases and 28 lesions (9.8%) involved locoregional recurrences of PCa. The median SUVmax value was significantly higher for PSMA compared to Choline for all 286 lesions (8.26 vs. 4.99 respectively, p<0.001). There were statistically significant differences in median SUVmean, PSMA/FCH-TV and TL-PSMA/FCH between the two radiotracers (4.29 vs. 2.92, 1.97 vs. 1.53 and 7.31 vs. 4.37 respectively, p<0.001). TL-PSMA/FCH demonstrated statistically significant positive correlations with both PSA level and PSA velocity for both PSMA (r = 0.56, r = 0.57, p < 0.001) and Choline (r = 0.49, r = 0.51, p < 0.001). While patients who received hormone therapy showed higher median SUVmax values for both radiotracers compared to those who did not, the difference was statistically significant only for 18F-PSMA (p < 0.05). Our analysis demonstrated the improved performance of 18F-PSMA-1007 compared to 18F-Choline for calculating quantitative features in all metastatic lesions in PCa patients with BCR. Total lesion PSMA/FCH also showcased positive correlation with PSA level and velocity.

Health Sciences

Quantitative features, Radiotracers

No

0

Yes

48

71

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/3398809