Unit:
Κατεύθυνση Φυσιολογία της Γήρανσης και Γηριατρικά ΣύνδρομαLibrary of the School of Health Sciences
Author:
Davia Ioanna-Pinelopi
Supervisors info:
Αθανάσιος Μπενέτος, Καθηγητής, Ιατρική Σχολή, Université de Lorraine
Πέτρος Σφηκάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευρυδίκη Κραββαρίτη, Aκαδημαϊκή Υπότροφος, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Χρήση δυνητικώς ακατάλληλων φαρμάκων ως χρόνια φαρμακευτική αγωγή σε ηλικιωμένους νοσηλευόμενους μιας παθολογικής κλινικής και συσχέτιση με την αιτία προσέλευσης, την αιτία και την έκβαση της νοσηλείας
Translated title:
Use of potentially inappropriate medication as chronic medication in older hospitalized patients and assosiation with the causes and the outcomes of hospitalization
Summary:
Introduction: Use of potentially inappropriate medication in old patients has been linked to increased risk of side effects and healthcare system utilization. Purpose: This study aims to estimate the prevalence of inappropriate medication use in old hospitalized patients at admission and to investigate risk factors and the correlation with the causes and the outcomes of hospitalization.
Method: In this retrospective study, patients over 65 years of age, hospitalized in the internal medicine yard of a tertiary hospital, during 01/01-31/03/2023 were included. Demographics and clinical data were collected and STOPP criteria of STOPP/START criteria version 2 were used to review their chronic medication.
Results: A total of 233 patients (57% females, median age: 83 years) were included in our study. Potentially inappropriate medication was used among 61.8% of them. Most common criteria met were medication without evidenced-based clinical indication (criterion A1, 38,8%), neuroleptics (Κ2, 25.7%) and benzodiazepines (Κ1, 22.2%). Polypharmacy, multicomorbidity, dementia and depression were associated with inappropriate prescription (p-value<0.05 for all the aforementioned parameters). Users of potentially inappropriate medication had increased risk of hospitalization due to adverse drug reactions compared to non-users (18% vs 6.8%, p-value=0.01). There were no differences in the duration and the outcomes of hospitalization between the two study groups. Upon discharge, at least one inappropriate medication was stopped in 29.8% of the patients.
Conclusions: In our study, high prevalence of inappropriate prescription was recorded in old hospitalized patients. STOPP/START criteria can be used to increase pharmacovigilance and raise the awareness for a better management of geriatric patients.
Main subject category:
Health Sciences
Keywords:
Potentially inappropriate medication, STOPP/START Criteria
File:
File access is restricted only to the intranet of UoA.
Davia_Ioanna-Pinelopi_MSc.pdf
675 KB
File access is restricted only to the intranet of UoA.
