Unit:
Κατεύθυνση ΨυχιατροδικαστικήLibrary of the School of Health Sciences
Supervisors info:
Ιωάννης Μιχόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Δουζένης, Καθηγητής , Ιατρικής Σχολή, ΕΚΠΑ
Μαρία-Λουϊζα Ψαρρά, Διδάκτωρ, Εγκληματολογία, Πάντειο Πανεπιστήμιο
Original Title:
Μελέτη της εν τω βάθει εγκεφαλικής διέγερσης στην αντιμετώπιση της ψυχογενούς ανορεξίας-συστηματική ανασκόπηση και μετα-ανάλυση
Translated title:
Study of deep brain simulation in the treatment of anorexia nervosa - systematic review and meta-analysis
Summary:
The purpose of this study is to present the effectiveness of deep brain stimulation (DBS) for severe and treatment refractory anorexia nervosa.13 relevant studies were selected through the systematic review protocol in order to assess the level of response to the specific method, the clinical benefits of the treatment and its degree of safety. The following section contains the synthesis of the above results which was attempted in order to form a consolidated conclusion. In particular, from the value resulting from the Z-transformation (3.42), which is greater than the value of 1.96 of the standard normal distribution, combined with the fact that the p-value is equal to 0.0006, it is shown that according to this particular meta-analysis the use of DBS causes a statistically significant improvement in BMI increase in patients with anorexia nervosa that is refractory to conventional treatments. Specifically, the difference in favor of DBS was 1.14 (95% confidence interval= 0.49-1.80) and the heterogeneity was quite high (I2=67%). The findings of the study confirmed the clinical benefit of applying DBS to the patients, who mostly experienced weight gain, improved quality of life and improved depression, mood and anxiety levels. Although the safety of the method has not been extensively studied, complication rates have shown it to be a relatively safe procedure, with relatively limited side effects. Of course, in order to be able to fully evaluate DBS, a thorough investigation of its safety rate and long-term side effects becomes necessary. In any case, the encouraging findings so far indicate that there is a possible indication for its application when conventional treatment methods fail to offer a solution while they also underline the need for further research both in relation to the individual parameters of the procedure and in relation to its level of efficacy and safety.
Main subject category:
Health Sciences
Keywords:
Anorexia nervosa, Deep brain stimulation, Body mass index, Systematic review, Meta-analysis
