Unit:
Κατεύθυνση Ανάπτυξη Νέων Φαρμάκων: Έρευνα, Κυκλοφορία και ΠρόσβασηLibrary of the School of Health Sciences
Author:
Kakavouli Georgia
Supervisors info:
Ουρανία Τσιτσιλώνη, Καθηγήτρια, Τμήμα Βιολογίας, ΕΚΠΑ
Ηλίας Κοττέας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γαρυφαλλιά Πουλάκου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σημασία της παρουσίας ελάχιστης υπολειμματικής νόσου (MRD) μετά από ανοσοθεραπεία στην AL αμυλοείδωση
Translated title:
Significance of minimal residual disease (MRD) presence after immunotherapy in AL amyloidosis
Summary:
Primary systemic (amyloid light chain, AL) amyloidosis constitutes a rare
and severe hematologic malignancy associated with the production of
monoclonal light chains that form amyloid deposits in different tissues and organs. This disease affects the bone marrow and is characterized by the extensive deposition of insoluble amyloid fibrils in various tissues, leading to severe dysfunctions in organs such as the kidneys, heart, liver, and Peripheral Nervous System (PNS). Within the scope of this work, a detailed study is conducted on the biology of the blood and bone marrow, as well as on the role of immunoglobulins in AL amyloidosis.
Furthermore, emphasis is given on the pathophysiology, clinical
presentation, epidemiology, and methods for the diagnosis of primary
systemic amyloidosis. Finally, the significance of minimal residual disease (MRD) is highlighted as a prognostic biomarker in amyloidosis, along with an analysis of the principles of flow cytometry, as a major technique applied for MRD detection.
Main subject category:
Health Sciences
Keywords:
Amyloidosis, Minimal residual disease, Flow cytometry
File:
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Thesis-Georgia Kakavouli_Final (1).pdf
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