Unit:
Κατεύθυνση Σακχαρώδης Διαβήτης και ΠαχυσαρκίαLibrary of the School of Health Sciences
Author:
Kyriazis Dimitrios
Supervisors info:
Τεντολούρης Νικόλαος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ρέμπελου Ελένη, Επίκουρη Καθηγήτρια, Πανεπιστήμιο Τούρκου, Φινλανδία
Μακρυλάκης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση των ινκρετινών σε μεταβολικές παραμέτρους στο σακχαρώδη διαβήτη τύπου 1
Translated title:
The effect of incretins metabolic parameters on type 1 diabetes mellitus
Summary:
Diabetes mellitus is a disease with a wide field of research worldwide due to its increasing incidence. The scientific community is dedicated to discovering new therapeutic approaches to combat the disease, as well as its effects. Type 2 Diabetes Mellitus (T2DM) is a result of the modern lifestyle and the metabolic syndrome (MS), its main pathophysiological background follows the growing trends of obesity worldwide. This increasing tendency of the disease in the population has made it imperative to find new therapeutic protocols.
Incretin analogues have rapidly entered our therapeutic potential in the last decade, which were initially directed at the treatment of T2DM and obesity, the "epidemic" for many of the 21st century. Type 1 Diabetes Mellitus (T1DM), an autoimmune disease, is an insulin-treated disease par excellence. However, in combination with the increase in the incidence of obesity and MS in general, more and more patients have characteristics of many pathological entities. Our increasing knowledge of the pathophysiological background of the disease has led researchers to turn to newer additional therapeutic approaches, except from the classic insulin approach, such as pharmaceutical agents that could prevent the loss of β-cell mass. In the present literature review, the position of incretin analogues in T1DM will be investigated, with a view to the pathophysiological pathways that could be a target of incretins.
Main subject category:
Health Sciences
Keywords:
Incretins, Diabetes mellitus type 1
Number of references:
149
File:
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ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ.pdf
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