Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Chlapoutakis Konstantinos
Supervisors info:
Μπαλτάς Χρήστος, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Αντώνιος Γαλανός, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Αλεξία Μπαλανίκα, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Συγκριτική αξιολόγηση των κλινικών δεικτών εκτίμησης του κινδύνου οστεοπόρωσης, σε μετεμμηνοπαυσιακές γυναίκες ηλικίας 50-64 ετών, που υποβλήθηκαν σε μέτρηση οστικής πυκνότητας με τη μέθοδο DXA, στο νησί της Κρήτης
Translated title:
Comparative evaluation of osteoporosis clinical risk assessment tools, in postmenopausal women aged 50-64, undergoing DXA examination for the assessment of bone health, in the island of Crete, Greece.
Summary:
Objectives: To assess the performance of five osteoporosis clinical risk assessment tools (SCORE, ORAI, ABONE, OST and OSIRIS), in identifying the subgroup of young postmenopausal women aged 50-64, who will benefit from DXA screening.
Methods: The above-mentioned osteoporosis risk assessment tools were calculated for 258 young postmenopausal women (aged 50-64) who had a DXA scan, in Crete/Greece.
Results: Patients with a T-score ≤-2.5 or a T-score ≤ -2.0 had a statistically significant higher value of SCORE, ORAI and ABONE and a lower value of OST, OSIRIS, and OSIRIS Adjusted Score, compared to the patients with T-score >-2.5 and T-score >-2.0, respectively. ORAI (T-score≤-2.0) and OST (T-score≤-2.5) demonstrated the highest sum of sensitivity and specificity. CHAID analysis further confirmed the relative significance of the OST tool in the osteoporosis group (T-score≤-2.5 vs. T-score >-2.5), for a cut-off of 2.8. In the other group (T-score ≤-2.0 vs T-score >-2.0) the ORAI score showed a significantly important relationship for a cut-off of 8.
Conclusion: OST, despite its performance limitations, constitutes an attractive screening tool, which may identify a subgroup of the young (50-64), postmenopausal osteoporotic women, who would benefit from DXA screening.
Main subject category:
Health Sciences
Keywords:
DXA, Osteoporosis, Osteoporosis clinical risk assessment tools, Osteoporosis screening, Postmenopausal women
File:
File access is restricted until 2025-01-15.
Διπλωματική Εργασία - Χλαπουτάκης Κωνσταντίνος.pdf
2 MB
File access is restricted until 2025-01-15.
