Unit:
Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπουLibrary of the School of Health Sciences
Author:
Kavourakis Georgios
Supervisors info:
Πηνελόπη Κορκολοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χαρά Γακιοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννα Γιαννοπούλου, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μεταβολές της δομής της χρωματίνης στον καρκίνο του νεφρού
Translated title:
Chromatin modifications in renal cell cancer
Summary:
Renal cell carcinomas represent about 80-90 percent of all malignant kidney tumors and about 3 percent of all cancers in adults with more than 300.000 new cases each year worldwide. They appear increasing incidence and decreasing mortality during the last 50 years. Renal cell cancer is a malignant neoplastic disease characterized by histopathologic, genetic and molecular heterogeneity which impact to some degree on the classification, risk stratification and choice of therapy, mainly of the advanced disease. It is well known that genetic and epigenetic modifications contribute to the disease pathogenesis. The genetic modifications affect the DNA nucleotide sequence, while the epigenetic ones are mainly chemical changes in histones and DNA which modify the gene expression without affecting the nucleotide sequence of the DNA. The epigenetic regulation in the mammalian genome is achieved by the DNA methylation, the histone modifications and the regulation by non coding RNAs. DNA methylation and histone modifications are chromatin structure alterations. The deregulation of each or all of them appears not only to contribute to the initiation, progress, invasion and metastasis of renal cell cancer but also to be a promising field of research for biomarkers suitable for early detection, evaluation of prognosis and prediction of therapeutic response as well as target of new therapeutic interventions. In this study, we review the genetic and epigenetic modifications of the chromatin structure as they relate to the understanding of the molecular mechanisms implicated in the disease pathogenesis, progress and metastasis, diagnosis, classification, prognosis and therapeutic approach of renal cell cancer.
Main subject category:
Health Sciences
Keywords:
Renal cell cancer, Chromatin modifications
Number of references:
278
