Unit:
Speciality Cardiometabolic MedicineLibrary of the School of Health Sciences
Author:
Korakas Emmanouil
Supervisors info:
Λαμπαδιάρη Βάια, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Οικονομίδης Ιγνάτιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Οικονόμου Ευάγγελος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Αξιολόγηση του καρδιομεταβολικού κινδύνου σε ασθενείς με απόφραξη φλέβας αμφιβληστροειδούς
Translated title:
Cardiometabolic risk assessment in patients with retinal vein occlusion
Summary:
Background: Retinal vein occlusion (RVO) is a relatively uncommon condition with a complex pathophysiology, however, its association with traditional cardiovascular risk factors is well-established. In this study, we compared arterial stiffness and endothelial function between patients with RVO and healthy controls.
Materials and methods: We enrolled 28 consecutive patients with RVO, either central (CRVO) or branch (BRVO), and 30 healthy controls. We measured: (a) perfused boundary region of the sublingual arterial microvessels (marker of endothelial glycocalyx thickness), (b) pulse wave velocity (PWV), augmentation index (AIx) and central systolic blood pressure (cSBP).
Results: No statistically significant differences regarding age, gender and major cardiovascular risk factors were noted between patients and controls. Compared to controls, patients with RVO had higher PBR, PWV, Aix and cSBP values (p0,05).
Conclusions: Patients with RVO have reduced endothelial glycocalyx thickness and increased arterial stiffness compared to healthy controls. These findings further elucidate the role of atherosclerosis and endothelial dysfunction in the pathophysiology of the disease and indicate the need for evaluation of subclinical cardiovascular disease in these patients.
Main subject category:
Health Sciences
Keywords:
Retinal vein occlusion, Glycocalyx, Arterial stiffness, Pulse wave velocity, Atherosclerosis
