Unit:
Speciality Myoskeletal Oncology: Diagnosis-Treatment-ResearchLibrary of the School of Health Sciences
Supervisors info:
Στρατηγούλα Σακελλαρίου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πηνελόπη Κορκολοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ελευθερία Λακιωτάκη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ο ρόλος της σηματοδοτικής οδού Hedgehog στην ογκογένεση των σαρκωμάτων
Translated title:
The role of hedgehog signalling pathway in sarcoma tumor genesis
Summary:
By elucidating the complex molecular mechanisms driving carcinogenesis, scientists aim to
identify novel biomarkers for timely diagnosis, prognosis estimation and therapy monitoring. The Hedgehog (HH) signalling pathway is a key molecular mechanism that participates in a plethora of developmental and physiological processes, including stem cell differentiation and tissue homeostasis. Current research has demonstrated that HH pathway is implicated in a number of tumorigenic procedures, namely cell proliferation, migration, activation of anti-apoptotic mechanisms and instigation of epithelial-mesenchymal transition. Researchers have associated the expression of various HH pathway participants with a multitude of cellular mechanisms as well as clinicopathological parameters, including patients’ overall survival, radiotherapy and chemotherapy resistance, rendering them as potential targets for novel, personalized and effective therapeutic strategies. In the present study we gathered and concisely present the data reported
from research works investigating the role of the HH pathway in bone and soft tissue tumors.
Main subject category:
Health Sciences
File:
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SHH 2.7.2024-final.pdf
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File access is restricted only to the intranet of UoA.
