Unit:
Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Author:
Karatasos Charalampos
Supervisors info:
Μαυρογιάννη Δέσποινα, Ε.ΔΙ.Π., Ιατρική Σχολή, ΕΚΠΑ
Δρακάκης Πέτρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταύρος Σοφοκλής, Επ. Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Φαρμακογενωμική και εξωσωματική γονιμοποίηση
Translated title:
Pharmacogenomics and in vitro fertilisation
Summary:
In vitro fertilisation (IVF) has revolutionised assisted reproductive technology, offering hope to couples struggling with infertility. Despite all advancements, IVF outcomes remain variable and are, influenced by numerous factors, including genetic variations such as polymorphisms. This thesis explores the role of various polymorphisms in determining the success rates of IVF procedures, by mainly focusing on studies published since 2017. Through an extensive review of the literature, genetic databases, and clinical data, this thesis aims to study the relationship between specific polymorphisms and key IVF outcomes, including fertilisation rates, embryo quality, implantation success, and live birth rates. Additionally, this thesis explores the underlying mechanisms by which these genetic variations impact reproductive processes, shedding light on potential biomarkers for predicting IVF success and guiding personalised treatment strategies. By providing insights into the genetic determinants of IVF outcomes, this thesis contributes to the optimisation of assisted reproductive techniques, ultimately improving the chances of success for couples undergoing IVF procedures.
Main subject category:
Health Sciences
Keywords:
Pharmacogenomics, Polymorphism, Infertility, IVF, In vitro fertilisation
