Unit:
Κατεύθυνση Ιατρική Γενετική: Κλινική και Εργαστηριακή ΚατεύθυνσηLibrary of the School of Health Sciences
Author:
Chalaf Noura-Eleonora
Supervisors info:
Θάλεια Μαμά, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Χριστίνα Βρεττού, Εργαστηριακό Διδακτικό Προσωπικό Γενετικής, Ιατρική Σχολή, ΕΚΠΑ
Γεωργία Κάκουρου, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Γενετικός ανασυνδυασμός σε γαμέτες και έμβρυα
Translated title:
Genetic recombination in human gametes and embryos
Summary:
BACKGROUND
Meiosis is a type of cell division by which each parent produces its gametes, which with their fusion form the zygote, from which the somatic cells of the organism will be formed by mitotic divisions. One of the most important events that occur in meiosis is genetic recombination which involves the exchange of genetic material between segments of DNA and includes homologous and non-homologous recombination. There are methods by which we can estimate recombination, which occurs when the segments to be recombined are far apart. In meiosis, the model of homologous recombination is followed, and it helps in genetic diversity as well as in the proper segregation of chromosomes.
PURPOSE
The purpose of this literature review is to study the recombination that occurs in meiotic division and its effects on the production of gametes and consequently on the creation of fetus.
METHODOLOGY
The method followed involves gathering articles from the appropriate databases and recording the information that covers our research questions.
RESULTS
After studying several articles, it was found that there are factors related to the recombination phenomenon. Ιt was observed that the rate of recombination changes according to the size of the chromosome, with smaller chromosomes showing a higher average recombination rate. It was also observed that the rate of recombination decreases as the age of the mother increases. Finally, it was found that there are differences in the rates of recombination between the two sexes. In particular, a higher frequency of meiotic recombination is observed in oocytes than in sperm.
CONCLUSIONS
Meiotic recombination is crucial for generating genetic diversity and normal gametes, with significant implications for reproductive health, particularly in the context of maternal aging and its impact on aneuploidy and fertility.
Main subject category:
Health Sciences
Keywords:
Reduction, Genetic recombination, Gametes
File:
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DIPLWMATIKH (1).pdf
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