Unit:
Speciality Infectious DiseasesLibrary of the School of Health Sciences
Author:
Nikolaou Georgios
Supervisors info:
Ηρακλής Τσαγκάρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καρολίνα Ακινόσογλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, Πατρών
Ευδοξία Κυριαζοπούλου, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Ένταση φλεγμονώδους αντίδρασης στη νόσο COVID - 19
Translated title:
Intensity of inflammatory responce in COVID - 19 disease
Summary:
Introduction: Inflammation is normal response of the organism that is activated reactively after the influence of various harmful factors. It is a complex process involving various cells and mediators that work together to eliminate the offending agent and promote healing. However, excessive or uncontrolled inflammation can cause tissue damage and contribute to the development of many diseases, including infections. The recent outbreak of the coronavirus disease COVID -19 has led to a global health crisis, with millions of cases and hundreds of thousands of deaths worldwide. The purpose of the present study is to study the immune behavior in patients with severe disease of COVID-19. The changes of specific mediators were studied and the correlations of these measurements are presented.
Method: In this study, the population of seriously ill intubated patients with COVID-19, adults: men - women, in the ICU of U.G.H ATTIKON they were analyzed for the number of circulating inflammatory mediators. Twenty patients intubated with active COVID-19 were included in the study. Blood (general - coagulation) samples were collected.
Result: Circulating concentrations of the interleukins IL-6, IL-17, IL-22, and the factors FGF-23, PDGF-A, SPG-130 were assayed. Differences in values between patients who survived and those who died on days 1 and 7 of sampling were investigated. A strong correlation was shown between interleukin IL-6 and SPG-130 agent.
Main subject category:
Health Sciences
Keywords:
IL-6, IL-17, IL-22, FGF-23, PDGF-A
