Unit:
Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική ΒιομηχανίαLibrary of the School of Science
Supervisors info:
Γεώργιος Χ. Βουγιουκαλάκης, Αναπληρωτής Καθηγητής, Τμήμα Χημείας, ΕΚΠΑ, (Επιβλέπων)
Σταματία Βασιλείου, Αναπληρώτρια Καθηγήτρια, Τμήμα Χημείας, ΕΚΠΑ,
Αναστασία Δέτση, Καθηγήτρια, ΕΜΠ
Original Title:
Ανάπτυξη καταλυτικών πρωτοκόλλων βαθέως ευτηκτικών συστημάτων και χρυσού και η εφαρμογή τους σε χρήσιμους οργανικούς μετασχηματισμούς
Translated title:
Development of deep eutectic catalytic protocols systems and gold and their application to useful organic transformations
Summary:
Research towards new, catalytic systems that can replace organic solvents and
metal catalysts based on palladium, ruthenium, rhodium, rhodium, iridium, etc.,
with cheaper, sustainable and less toxic reagents attracts major interest. In the
present thesis, the development of two independent catalytic systems was
studied. These systems include the replacement of organic solvents and
catalysts in reactions important for the Chemical Industry and the use of gold(I)
complexes using hexafluoroisopropanol (HFIP) as solvent for the synthesis of
quinolines.
The work commences with the synthesis of a deep eutectic solvent (DES), with
dual activity, both as a solvent and catalyst in esterification reactions. The esters
produced using this method are particularly important for the Chemical Industry,
as they are used as flavourings and food additives. The most important features
of the protocol developed are the possibility of recycling of the deep eutectic
system, mild reaction conditions, and the of the ester through a two-phase
equilibrium, from which the product is obtained in excellent yields and in a pure
form. Therefore, the protocol developed proves to be ideal for application in
industry following the principles of "Green Chemistry".
The second part of the thesis deals with the design of a protocol using gold(I)
complexes in HFIP solvent to form quinolines. This system comprises a special
catalysis mode in which HFIP acting both as a solvent and as an activator of the
complex. However, the above protocol was not extensively studied, and its
development reached the point where very encouraging results were observed
with the desired quinolines being formed in moderate to excellent yields using
extremely low catalytic charge.
Main subject category:
Science
Keywords:
sustainable catalysis, recyclability of catalyst, deep eutectic solvents, gold(I) complexes
Number of references:
159
File:
File access is restricted until 2027-10-30.
MSc Spyrou_final.pdf
4 MB
File access is restricted until 2027-10-30.
