Unit:
Κατεύθυνση Παθολογία της ΚύησηςLibrary of the School of Health Sciences
Supervisors info:
Σταυρούλα Α. Πάσχου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Σοφία Καλανταρίδου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Ευαγγελινάκης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σύνδρομο πολυκυστικών ωοθηκών και υπογονιμότητα
Translated title:
Polycystic ovary syndrome and infertility
Summary:
Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder affecting a significant proportion of women of reproductive age, characterized by a combination of hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. This syndrome is associated with a range of metabolic and reproductive complications, the most significant of which is infertility. Hormonal imbalances in PCOS disrupt normal ovulatory cycles, leading to anovulation or irregular ovulation, thereby impairing fertility. Additionally, PCOS is linked to insulin resistance, obesity, and associated metabolic disorders, further complicating reproductive outcomes. The pathophysiology of infertility in PCOS is multifaceted, involving alterations in folliculogenesis and the ovarian microenvironment. Current management strategies for infertility in women with PCOS include lifestyle modifications, pharmacological interventions such as ovulation induction agents, and assisted reproductive technologies. Understanding the underlying mechanisms and developing targeted treatment options are crucial for improving reproductive outcomes in this population. Continued research into the genetic, hormonal, and metabolic facets of PCOS will enhance our ability to address the infertility challenges faced by affected women.
Main subject category:
Health Sciences
Keywords:
Polycystic ovary syndrome, PCOS, infertility, Ovulation disorders, Hyperandrogenism, Insulin resistance, Hashimoto's thyroiditis, In vitro fertilization, IVF
Number of references:
240
