Unit:
Κατεύθυνση Μεταβολικά Νοσήματα των ΟστώνLibrary of the School of Health Sciences
Author:
Inglezos Nikolaos
Supervisors info:
Κωνσταντίνος Σταθόπουλος, Επιστημονικός Συνεργάτης, Ιατρική Σχολή, ΕΚΠΑ
Χρονόπουλος Ευστάθιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λάμπρου Γεώργιος, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Σύγχρονη αντιρετροίκη αγωγή και κίνδυνος καταγματος
Translated title:
Modern antiretroviral therapy and fracture risk
Summary:
Excessive bone loss has been noticed in HIV patients, under no antiretroviral therapy, suggesting that HIV is an independent factor for osteoporosis. However, it is still controversial if bone mineral density reduction and increased fracture risk is related to HIV itself or to antiretroviral therapy, with a contribution from both likely. The purpose of this study is to review the association of modern antiretroviral drugs with fracture risk. A simple literature review was performed in the Pubmed database. Studies were searched using the following keywords: ("antiretroviral" OR "HAART" OR "NRTIs" OR "nucleoside reverse transcriptase inhibitors" OR "fosamprenavir" OR "indinavir" OR "lopinavir" OR "nelfinavir" OR " ritonavir" OR "saquinavir" OR "tipranavir" OR "abacavir" OR "emtricitabine" OR "lamivudine" OR "stavudine" OR "zidovudine" OR "doravirine" OR "efavirenz" OR "etravirine" OR "nevirapine" OR "rilpivirine" ) AND ("fracture risk" OR "risk of fracture"). The final search identified 22 studies (6 prospective randomized studies, 4 prospective cohort studies, 3 cross-sectional studies, 4 case–control studies, and 5 retrospective studies). It appears that the pathogenesis of osteoporotic fractures in AIDS patients is multifactorial. The majority of studies show mixed results regarding the effect of most antiretroviral drugs. Further high-quality research is needed to fully elucidate the role of antiretroviral drugs in the pathogenesis of osteoporotic fractures in HIV-infected patients.
Main subject category:
Health Sciences
Keywords:
AIDS, HIV, Antiretroviral therapy, Osteoporosis, Bone mineral density, Fracture risk
Number of references:
120
