Department of Pharmacy
Library of the School of Science

2024-12-06

2024

Skyriotis Konstantinos
Meidani Maria

Ευσταθία Ιωάννου, Αναπληρώτρια Καθηγήτρια, Τμήμα Φαρμακευτικής ΕΚΠΑ (Επιβλέπουσα),
Βασίλειος Ρούσσης, Καθηγητής, Τμήμα Φαρμακευτικής ΕΚΠΑ,
Στέφανος Κικιώνης, Επίκουρος Καθηγητής, Τμήμα Φαρμακευτικής ΕΚΠΑ

Απομόνωση δευτερογενών μεταβολιτών από ροδοφύκος του γένους Laurencia

Greek

Isolation of secondary metabolites from red algae of the genus Laurencia

In the framework of the present thesis, the chemical profile of the organic extract of a
red alga of the genus Laurencia was studied. Specimens of the red alga Laurencia sp. (MP0314) were collected from the coastal rocks in Firiplaka beach at Milos island at a depth of 0,5-2 m in July of 2017.
Initially, the organism was subjected to exhaustive extraction with organic solvents.
The extract was then concentrated under vacuum and the organic residue was subjected to a
series of chromatographic separations, leading to the isolation of seven secondary
metabolites. Subsequent analysis of their spectroscopic data (NMR and MS) and comparison
with literature data led to their structure elucidation.
More specifically, the following metabolites were isolated and identified:
i. four C15 acetogenins: two with a tetrahydropyran ring (1 and 2), one laurenane-type
with an eight-membered ring (3) and one with a tetrahydropyran and a
tetrahydrofuran ring (4),
ii. two sesquiterpenes: one linear (5) and one monocyclic (6) and
iii. one steroid (7).

Science

Isolation, Laurencia, red algae, natural products, structural characterization

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/3446268