Unit:
Κατεύθυνση Αρτηριακή Υπέρταση και Συνοδά Καρδιαγγειακά-Νεφρικά ΝοσήματαLibrary of the School of Health Sciences
Author:
Stathoulopoulou Maria
Supervisors info:
Τσιούφης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Τσιαχρής Δημήτριος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γκατζούλης Κωνσταντίνος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επίδραση της νεφρικής απονεύρωσης στη δραστηριότητα του συμπαθητικού νευρικού συστήματος
Translated title:
Effect of renal denervation on sympathetic nervous system activity
Summary:
The role of the sympathetic nervous system in the pathophysiology of arterial hypertension has been highlighted through preclinical studies of various hypertension models, as well as from observational studies mainly of transplanted patients. The quantification of sympathetic nervous system activity in clinical studies in humans is difficult, with the norepinephrine spillover and microneurography being the two most prevalent methods. Studies in both animals and humans have highlighted the ability of renal sympathetic denervation to reduce the levels of sympathetic activity and consequently the blood pressure in various ways, while the application site of the ablation, playing a crucial role in the success of the method. The re-innervation observed after some time following the denervation cannot currently be characterized as functional.
Main subject category:
Health Sciences
Keywords:
Sympathetic nervous system, Renal denervation, Sympathetic activity, Arterial hypertension
Number of references:
143
