The impact of nutrition on sarcopenia and performance in patients with type 2 diabetes

Doctoral Dissertation uoadl:3460735 19 Read counter

Unit:
ΠΜΣ Φυσική Αγωγή και Αθλητισμός
Library of the School of Physical Education and Sport Science
Deposit date:
2025-01-29
Year:
2025
Author:
Argyropoulou Dionysia
Dissertation committee:
Βασίλειος Πασχάλης, Αναπληρωτής Καθηγητής, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Νικόλαος Γελαδάς, Καθηγητής, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Τζώρτζης Νομικός, Αναπληρωτής Καθηγητής, Τμήμα Επιστήμης Διαιτολογίας-Διατροφής, Χαροκόπειο Πανεπιστημίο
Μιχαήλ Νικολαΐδης, Καθηγητής, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
Γεράσιμος Τερζής, Καθηγητής, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Μαρία Μαράκη, Επίκουρη Καθηγήτρια, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Νικόλαος Μαργαριτέλης, Επίκουρος Καθηγητής, Τμήμα Επιστήμης Φυσικής Αγωγής και Αθλητισμού, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
Original Title:
Η επίδραση της διατροφής στη σαρκοπενία και στην απόδοση σε ασθενείς με διαβήτη τύπου ΙΙ
Languages:
Greek
Translated title:
The impact of nutrition on sarcopenia and performance in patients with type 2 diabetes
Summary:
Introduction: Supplemental protein intake has been proposed as an effective nutritional strategy for maintaining muscle mass in the elderly. However, Type 2 Diabetes (T2D) contributes to muscle mass loss, and as a result, elderly individuals with T2D often develop sarcopenia, which in turn exacerbates T2D. Given that T2D affects muscle mass, our objective was to evaluate the impact of increased protein intake on factors related to sarcopenia, muscle oxygenation, the quality of the nutritional intervention, and the progression of T2D in middle-aged and older individuals with T2D. Methodology: Twenty-six individuals (age >50 years) with T2D volunteered to participate in this study. In a 12-week randomized trial, the control group (CG) received 0.8-1.0 gr/kg/day of protein, while the intervention group (IG) received 1.2-1.5 gr/kg/day of protein. Body composition, muscle mass, muscle strength, muscle oxygenation, and hematological-biochemical parameters were measured before and after the intervention period to assess changes in muscle mass loss and the progression of T2D. Results: The IG showed significant improvements (p<0.05) in muscle strength and physical performance. A significant improvement was also observed in the amino acid profile, reaching current recommendations. In contrast, the CG experienced significant decreases (p<0.05) in lean body mass, skeletal muscle index, and muscle strength. No significant effects were observed on muscle oxygenation, blood markers, or biochemical parameters, except for high-density lipoprotein (HDL) (p=0.023) in the IG. Surprisingly, a protein intake of 0.8-1.0 gr/kg/day is insufficient to meet current recommendations for amino acid intake. Conclusion: The current recommendation for protein intake is insufficient for improving muscle mass loss or for enhancing nutritional quality in middle-aged and older individuals with T2D. A protein intake of 1.2-1.5 gr/kg/day appears to be a more appropriate recommendation to combat the onset of sarcopenia, though not for improving T2D markers. This higher intake also seems to be a more suitable option for achieving the current recommendations for amino acid intake.
Main subject category:
Education - Sport science
Keywords:
sarcopenia, type 2 diabetes, performance, protein, amino acids, muscle oxygenation
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
211
Number of pages:
162
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