Unit:
Department of ChemistryLibrary of the School of Science
Dissertation committee:
ΑΝΑΣΤΑΣΙΟΣ ΟΙΚΟΝΟΜΟΥ, Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
ΧΡΗΣΤΟΣ ΚΟΚΚΙΝΟΣ,Αναπληρωτής Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α.
ΠΑΝΑΓΙΩΤΑ ΠΕΤΡΟΥ, Ερευνήτρια Α’, ΕΚΕΦΕ Δημόκριτος
ΜΑΜΑΝΤΟΣ ΠΡΟΔΡΟΜΙΔΗΣ, Καθηγητής, Τμήμα Χημείας, Πανεπιστήμιο Ιωαννίνων
ΕΥΑΓΓΕΛΟΣ ΓΚΙΚΑΣ, Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
ΕΥΑΓΓΕΛΟΣ ΜΠΑΚΕΑΣ, Καθηγητής, Τμήμα Χημείας, Ε.Κ.Π.Α
ΔΗΜΟΣΘΕΝΗΣ ΓΚΙΩΚΑΣ, Καθηγητής, Τμήμα Χημείας, Πανεπιστήμιο Ιωαννίνων
Original Title:
Development and applications of novel paper-based analytical devices
Translated title:
Development and applications of novel paper-based analytical devices
Summary:
Recently, paper-based analytical devices (PADs) have attracted the interest of researchers in the fields of analytical chemistry and (bio)sensing. Paper offers significant advantages for analytical applications as a functional platform of sensing devices. It is a hydrophilic, cheap, biocompatible, environmentally friendly material and contains active groups that are suitable for immobilizing biomolecules. In addition, (bio)chemical analysis can be achieved on paper substrate with very small sample volumes while the flow of solutions is implemented through capillary effects without the intervention of pumps. Finally, PADs can be readily combined with portable instrumentation for optical and electrochemical detection. The overall aim of this thesis is the design, fabrication and implementation of novel PADs. Initial experiments explored the fabrication of PADs using x-y plotting. Fluidic channels were designed using a computer-aided design (CAD) program and channels with hydrophobic barriers were drawn on paper substrates with hydrophobic commercially-available markers using an x-y plotter. Different types of paper with different properties and different types of permanent markers were investigated. The PADs were evaluated in terms of their capillary action and their tolerance towards different solvents. Subsequently, electrode arrays fabricated from conductive inks were deposited on the PADs by plotting and screen-printing. These electrochemical PADs (ePADs)were employed for the development of stripping voltammetry methodologies for trace metal analysis in environmental and food samples. Finally, the use of thermal printing was explored as a novel method for the formation of hydrophobic barriers and was implemented for the fabrication of PADs for optical detection of thiocyanide in human saliva.
Main subject category:
Science
Keywords:
paper-based analytical devices, screen-printing, plotting, thermal printing, electrochemical detection, optical detection, trace metals, thiocyanate
Number of references:
224
File:
File access is restricted until 2026-01-30.
ΔΙΔΑΚΤΟΡΙΚΟ Final _ DS.pdf
8 MB
File access is restricted until 2026-01-30.
