Εxpression of p53 and p63 in the urinary bladder neoplasms and correlation with other prognostic factors

Doctoral Dissertation uoadl:1305558 741 Read counter

Unit:
Τομέας Χειρουργικής
Library of the School of Health Sciences
Deposit date:
2013-03-13
Year:
2013
Author:
Στάιος Δημήτριος
Dissertation committee:
Καθηγητής Χ. Δεληβελιώτης, Αναπλ. Καθηγητής Ι. Καστριώτης, Επίκουρος Καθηγητής Ι. Αναστασίου (επιβλέπων)
Original Title:
Έκφραση του p53 και p63 στα νεοπλάσματα της ουροδόχου κύστης και συσχετισμός με άλλους προγνωστικούς παράγοντες
Languages:
Greek
Translated title:
Εxpression of p53 and p63 in the urinary bladder neoplasms and correlation with other prognostic factors
Summary:
The motive to perform this study was to assess the expression of p53 and p63 in
bladder neoplasia of patients undergoing radical cystectomy (because of
invasive bladder cancer and T1G3 tumours resistant to BCG treatment) and to
correlate the expression with prognostic factors such the stage of disease, the
grade of the disease and the survival and the significance of these in the
prognosis of patients.
We studied 100 cases of patients who underwent radical cystectomy in 2nd
Urological Department,University of Athens at Sismanoglio Hospital. Slices from
paraffin blocks from the histological preparation of cystectomy stained in
Pathology Department of the upper Hospital, by immunohistochemisrty. The
patient follow-up was at least three years after radical cystectomy and became
either a telephone interview or examination in the outpatient clinic. The
statistical analysis of the results was performed with the statistical program
SPSS 19.00. The analysis of the study showed that it presented significant
relationship of p53 and p63 with prognostic factors mentioned above. A
multivariate analysis of the variables used did not result in a statistically
significant result and forth and detailed tables for each category comparison
of these results. The expression of p54 and p63 biomarkers studied
(individually and / or in combination) in patients who underwent radical
cystectomy due to invasive bladder CA and T1G3 resistant BCG therapy found to
have no statistically significant prognostic value. Although, it was found a
statistically significant difference with the stage of disease and the
expression of p53.
Keywords:
Urinary bladder cancer, p53, p63, Urethelial cancer, Prognostic factors
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
310
Number of pages:
155

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