Unit:
Τομέας Κοινωνικής Ιατρικής - Ψυχιατρικής και ΝευρολογίαςLibrary of the School of Health Sciences
Dissertation committee:
Σταμπουλής Ελευθέριος, Δαβάκη Παναγιώτα, Καρανδρέας Νικόλαος, Κυλιντιρέας Κωνσταντίνος, Ζαμπέλης Θωμάς, Ρέτζος Μιχαήλ, Αναγνωσούλη Μαρία
Original Title:
Ανοσογενετική μελέτη (HLA) και κλινικοεργαστηριακές συσχετίσεις της Χρόνιας Φλεγμονώδους Απομυελινωτικής Πολυνευροπάθειας (CIDP) στον ελληνικό πληθυσμό
Translated title:
Immunogenetic study (HLA) and clinical-laboratory correlations of the Chronic Inflammatory Demyelinating Polyneyropathy (CIDP) in a Kreek population
Summary:
The Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an acquired
heterogeneous disorder of autoimmune origin affecting the peripheral nerves,
causing motor weakness and sensory symptoms and sign. The precise
pathophysiology of CIDP remains uncertain although the disease is a result of
complex interactions between genetic and environmental factors. The disease is
associated with certain human leukocyte antigen (HLA) class II alleles in
various populations. In this study we aimed at determining, for the first time
in a Greek population, the association of HLA-DRB1* alleles and the subtypes
distribution in 40 patients with CIDP and in 97 healthy control individuals
(DNA typing for HLA-DRB1*) by using a DNA-based sequence-specific primer method
( PCR-Polymerase Chian Reaction). Chi-squared (X2 ) test and Bonferroni and
Benjamini-Yekutieli correction methods were applied in the statistical analysis
of the data. Significantly higher frequency of HLA-DRB1*11 (41.3% vs 28.9%,
p<0.065) was observed in CIDP patients, while HLA-DRB1*15 was significantly
decreased (1.3% vs 7.2%, p<0.075): this result was diametrically opposite with
the one of MS, the corrispondent of which is considered the CIDP in peripheral
nervous system. The HLA-DRB1*11 subtyping showed a significant increase of
DRB1*1104 (66.7% vs 17.9% p <0.0001) in CIDP patients, with significant high
frequency of this subtype in female patients (70% vs 16.1%, p <0.0001).
Conducting the first research of this kind in a Greek population, our study
aims at providing an evaluation of the prevalence of CIDP relating to
HLA-DRB1*1104 subtype for the calculation of the relative risk (RR) for CIDP in
a Greek population and for the evaluation of differences in prevalence of CIDP
relating to HLA-DRB1*1104 subtype between the sexes, considering the
epidemiological data of prevalence of 2 vs 1 for the males, characteristic of
the disease.
Keywords:
HLA, HLA-DRB1 alleles, MHC, CIDP, Immunogenetic study
Number of references:
219
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