Unit:
Τομέας ΚλινικοεργαστηριακόςLibrary of the School of Health Sciences
Author:
Πουλαντζάς Βασίλειος
Dissertation committee:
Καθ Α. Γουλιάμος, Καθ Γ. Λυμούρης, Αν. Καθ. Α Σταύρακα
Original Title:
Αξιολόγηση της χορήγησης σημασμένου με Lu -177 Dotatate μετά από καθετηριασμό της ηπατικής αρτηρίας σε νευροενδοκρινούς χαρακτήρα ηπατικές μεταστάσεις
Summary:
Purpose: The aim of this study is to evaluate the effectiveness of
Lu-177-DOTA-TATE infusions after selective catheterization of the hepatic
artery in inoperable liver metastasized sst2 receptor-positive neuroendo-crine
tumours due to the effect of β- emission, minimising in parallel the toxicity
of non-target tissue.
Methods: The average dose per session administered monthly to each patient (14
cases in total) was 6.3±2.3 GBq. Repetitions did not exceed 6-fold. Response
assessment was classified according to the RECIST criteria. CT/ MRI scans were
performed before and after the end of treatment; monthly ultrasound scans were
performed for follow-up. Toxicity (WHO criteria) was measured using blood and
urine tests for renal, hepatic and bone marrow function.
Results: Νone patient has achieved complete response [CR], partial response[PR]
was shown in 9/14 (65%), and disease stabilization[SD] in 2/14 (14%) patients;
three patients (21.0%) did not respond [PD]. Grade 1 myelotoxicity occurred in
8 cases, grade 2-3 in 4 and grade 4 in 2 (blood transfusion).
Conclusion: In unresectable metastatic liver lesions, positive for somatostatin
receptors repeated, trans-hepatic infusions of Lu-177-DOTA-TATE showed an
effective therapeutic outcome. No nephro- or liver- toxicity has so far been
observed. Myelo- toxicity was appro-priately managed.
Keywords:
Lu-177-DOTA-TATE, Therapeutics , Transhepatic arterial infusions, Infusions, Liver metastases
Number of references:
116
