Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences

2014-03-31

2014

Θεοδωρίδου Καλλιόπη

Συριοπούλου Βασιλική

Διαχρονική μελέτη της ΗIV λοίμωξης σε παιδιά και εφήβους στην Ελλάδα

Greek

Longitudinal study of HIV infection in children and adolescents in Greece

The present study includes a:
Ι. A retrospective part with data of the pediatric AIDS unit of Aghia
Sophia Childrens Hospital from the period 1985 – 2011 and
ΙΙ. A prospective part aiming to investigate the non-traditional
adipokines which are involved in lipodystrophy an important adverse effect of
antiretroviral treatment of HIV infected patients.
Ι. RETROSPECTIVE PART
Ιa. This part includes data from multitransfused children and
adolescents (Haemog¬lo¬binopathies, Haemophiliacs) who were infected with HIV
before 1985, Total No 43.
Ιb. Data of vertically infected children or infected from unknown
source, Total No 62.
Ιc. Data of babies of HIV (+) mothers from 1985 – 2011, Total No 163.
a) Patients of the first group did not have the chance of antiretroviral
treatment and the majority have succumbed while few were followed up in adults
AIDS units.
b) Patients of the second group had received antiretroviral treatment in
various stages of their disease. The majority of patients are alive with a good
quality of life. The main concerns are the immediate and future adverse effects
of the antiretroviral treatment.
c) Babies of this group were born from HIV (+) mothers (1985 – 2011). As it is
well known from 1994 the recommended chemoprophylaxis with AZT during
pregnancy, labor and to the newborn has reduced the risk of mother to child
transmission (MTCT) of HIV from 25% to 8%.
A number of 163 babies were followed up. It is worth noticing that only during
the last 3 years the chemoprophylaxis is satisfactory implemented, but still
there is much to be done for the effective prevention.
II. PROSPECTIVE STUDY
Background. Lipodystrophy characterized by adipose tissue redistribution and
lipid and glucose metabolism abnormalities, is common among HIV-infected adults
and children on highly-active-antiretroviral-therapy (HAART). In a previous
study of HIV-infected children, we did not detect insulin resistance, despite a
high percentage of body fat redistribution abnormalities.
Conclusions. This study is the first one to demonstrate that a-FABP could be a
useful marker in unraveling central fat accumulation in HIV-infected children
on highly-active-antiretroviral-therapy. Extended prospective studies are
needed to confirm these results.

HIV, Children, Adolescence, Greece, Lipokines

No

0

Yes

164

126

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https://pergamos.lib.uoa.gr/uoa/dl/object/1305977