Unit:
Τομέας ΧειρουργικήςLibrary of the School of Health Sciences
Author:
Γιάλλουρου Αννέζα
Dissertation committee:
Ευστάθιος Παπαλάμπρος, Ιωάννης Ψυχογιός, Εμμανουήλ Οικονόμου
Original Title:
Διερεύνηση της σχέσης των κυκλοφορούντων καρκινικών κυττάρων, δεικτών αποπτωτικής ομοιοστασίας και γενετικής ετερογένειας παραγόντων που την επηρεάζουν, στον καρκίνο του μαστού- κλινική σημασία
Translated title:
Association of circulating tumor cells, markers of apoptosis' homeostasis, and genetic heterogeneity of factors that influence apoptosis in breast cancer- Clinical relevance
Summary:
Purpose: The aim of this study was to prospectively examine the association of
FokI polymorphism in the Vitamin D Receptor (VDR) gene, as well as PvuII
polymorphism in the Estrogen Receptor (ESR) gene with histopathological
features and prognosis among women with histologically proven breast cancer,
and, the detection of circulating tumor cells (CTCs) with metastatic potential.
Methods: Patient characteristics, tumor histopathology, detection of CTCs, and
genotyping of VDR polymorphism variant (FokI) and ER polymorphism variant
(PvuII) were recorded. Patients were also routinely followed up.
Results: There was a significant difference regarding nodal stage (p<0.001)
between the different genotypes of FokI polymorphisms (FF, Ff, ff), even though
a trend was also detected in the frequency between ductal and lobular type, as
well as tumor size (p=0.07). When further analysis was performed regarding
patients whose polymorphism included the f allele, we found statistically
significant differences in tumor size (p<0.001), nodal stage (p=0.03), tumor
grade (p=0.04) and lymphovascular invasion (p<0.001), while no differences in
nodal status, distant metastases and tumor stage were noticed. No significant
associations were found between any of the PvuII polymorphism variants and
tumor histopathology and stage. No statistical significance was proven between
FokI polymorphism’s variants or f allele and overall or progression-free
survival. Statistically significant associations between overall and
progression-free survival and PvuII polymorphism’s variants was demonstrated
(p<0.001). No statistical significance was depicted between CTCs’ detection and
any of the polymorphisms’ variants.
Conclusion: The f allele was associated with the presence of lymphovascular
invasion and poorly differentiated tumors, whereas the PP genotype was
associated with increased overall and progression-free survival, suggesting
that this variant is related to a more favorable prognosis.
Keywords:
Apoptosis, Circulating tumour cells, FokI polymorphism, PvuII polymorphism, Breast cancer
Number of references:
269
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