Determination of the role of biomolecules osteopontin (opn) and osteoprotegerin (opg) in patients with aneurysmal disease of the abdominal aorta and its correlation with both the extent and the type of therapeutic repair.

Doctoral Dissertation uoadl:1308020 96 Read counter

Unit:
Τομέας Χειρουργικής
Library of the School of Health Sciences
Deposit date:
2015-02-09
Year:
2015
Author:
Μαρτινάκης Βασίλειος
Dissertation committee:
Ιωάννης Μπράμης, Κωνσταντίνος Φίλης, Δημήτριος Θεοδώρου
Original Title:
Προσδιορισμός του ρόλου των βιομορίων osteopontin (opn) και osteoprotegerin (opg) σε ασθενείς με ανευρυσματική νόσο της κοιλιακής αορτής και συσχέτιση τόσο με την έκταση της νόσου όσο και με το είδος της θεραπευτικής της αποκατάστασης.
Languages:
Greek
Translated title:
Determination of the role of biomolecules osteopontin (opn) and osteoprotegerin (opg) in patients with aneurysmal disease of the abdominal aorta and its correlation with both the extent and the type of therapeutic repair.
Summary:
Aim of the study: Although there are studies showing an association between OPN
and OPG with abdominal aortic aneurysms (AAAs), no association of these two
biomarkers with AAA treatment, either surgical or endovascular, has been
reported. In our study, both preoperative and postoperative serum levels of
these molecules were measured in patients with AAA. In addition a possible
association of these molecules with the anatomic extent of AAA, was studied.
Material and Methods: In this prospective study seventy-four patients, with an
infrarenal AAA, were selected as candidates for an open or endovascular repair.
All aneurysms were classified (Types A–E) according to aneurysmal extent. All
patients had preoperative serum OPN and OPG values measurements and 1 week
after the procedure. Preoperative and postoperative values were compared with a
control group of twenty patients that were undergone an inguinal hernia repair.
Results: Preoperative OPN values in patients with any type of aneurysm were
higher than in the control group, while OPG values showed no statistical
significant difference. When comparing postoperative versus preoperative values
of these molecules in all AAA patients, we observed an increase of
postoperative values of both OPN (p=0,001) and OPG (p=0,01) molecules. OPN
values increased both after open surgery (p=0,025) and after EVAR (p=0,017). On
the other hand, OPG values increased after open surgery (p=0,02) but not after
EVAR. Moreover, postoperative OPN values in all AAA patients were higher than
the control group (p=0,005). Additionally, there was no difference in OPN/OPG
values between EVAR and open surgery postoperatively.
Conclusions: While OPN values are associated with aneurysm presence, they are
not associated with aneurysm anatomical extent. On the contrary, OPG values are
not associated either with aneurysm presence or with aneurysm extent. OPN
values increase after AAA repair, independently of the type of repair. There
was an increase of postoperative OPG levels only in AAA patients that underwent
surgical repair.
Keywords:
Osteopontin (opn), Osteoprotegerin (opg), Abdominal aortic aneurysm, Surgical aneurysm repair, Endovascular aneurysm repair
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
415
Number of pages:
237

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