Correlation between EGFR mutations and female hormone receptor expression in patients with lung adenocarcinoma

Postgraduate Thesis uoadl:1309821 1171 Read counter

Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences
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Πέττα Βασιλική
Supervisors info:
Καθηγητής, Κωνσταντίνος Ν. Συρίγος
Original Title:
Προσδιορισμός της συσχέτισης ανάμεσα σε μεταλλάξεις του EGFR και της έκφρασης υποδοχέων ορμονών φύλου σε ασθενείς με αδενοκαρκίνωμα πνεύμονα
Translated title:
Correlation between EGFR mutations and female hormone receptor expression in patients with lung adenocarcinoma
INTRODUCTION EGFR mutations are more common in lung adenocarcinoma, in female
patients of East-Asian origin and never or light smokers. Studies have shown
that more EGFR mutations are seen in tumors with ER positivity. However, ERα,
ERβ, PR and Her-2 expression in lung adenocarcinoma are present but limited.
AIM Correlation between EGFR mutations and female hormone receptor expression
in lung adenocarcinoma, recording of age, sex, body mass index (BMI), smoking
habit and comorbidities. Τo identify if patients, regardless of sex and the
existence of EGFR mutation, are female hormone receptor positive and whether
this positivity is higher in EGFR mutants. Aims if ER negative patients present
with higher prevalence for obesity, diabetes and cardiovascular disease.
METHODS 25 patients with lung adencarcinoma and already known EGFR status were
studied retrospectively. Detection of antibodies of female hormone receptors
(ER, PR, cerb2) was performed in biopsy specimen, according to
immunohistochemistry method of three steps. Epidemiological and clinical data
also recorded. 5 patients excluded because diagnosis was placed by cytological
RESULTS 80% were male and 20% female. Higher percentage of EGFR (-) and PR(+)
were male (p value <0.001 and 0.025, retrospectively). EGFR (-) were smokers
more often than EGFR (+) patients (p value=0.024). EGFR(-) expressed PR
positivity more often and had higher frequency of rheumatoid arthritis (p
value=0.044 and 0.019 retrospectively), whereas EGFR (+) presented more often
with asthma (p value=0.019). PR (+) presented more often with cardiovascular
disease (p value=0.033) and ER (-) presented more often with obesity (p value=
0.014). No other significant difference was observed between the examined
CONCLUSIONS The results confirm the suggestions of pre-existing studies that
female hormone receptors are present, regardless of sex and EGFR mutations and
therefore do not account for the high prevalence of lung adenocarcinoma among
women. Furthermore, the absence of estrogen receptors is associated with high
prevalence for obesity.
Lung adenocarcinoma, EGFR mutations , Female hormone receptors (ER, PR, cerb2), Obesity, Cardiovascular disease
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