Summary:
The challenge for optimal, effective and safe use of transfused blood is a
primary goal of a health system and has led to the improvement of current
laboratory
techniques and the development of new ones. This thesis refers to the pathogen
reduction technologies. It presents inactivation techniques that were already
licensed
and implemented both in Greece and internationally, and techniques that are in
progress, classified according to the mechanism of action (physical, chemical,
biological-photodynamic) and their application in stable and unstable blood
derivatives.
There are four main parts which are developed, firstly, the mechanism of
action of each technique, secondly, the effectiveness on each derivative-after
the
procedure step- such us the recovery of proteins and coagulation factors, the
viral,
bacterial and parasites reduction thirdly, the safety assessed with the
occurrence or
not of adverse events, developing of neo-antigens, the potential of toxicity,
carcinogenesis, developing immune response after transfusion of the possessed
derivatives and finally, the cost and the financial consequences arising of the
use of
these techniques.
The outcome of this project is based on sources by recent literature including
books,
articles and scientific researches to cite new scientific evidence and studies
which
are being developed
