Summary:
Introduction: the CRP is the most widely used acute phase protein. Measuring
the levels of CRP may help in the diagnosis between inflammatory and
non-inflammatory diseases, in monitoring the activity of various diseases, as
well as the prognosis of certain diseases. Although is not a specific
indicator, correlate strongly with cardiovascular risk. The ease which it is
measured, and the availability of the method makes it attractive as an
indicator for assessing the inflammatory condition of the heart disease
patients.
Material-method: The sample of the study were 164 patients were introduced in
the A’ Department of Cardiology Hippokration General Hospital of Athens who
suffered from coronary disease and had an indication for new control. To the
patients of the study was taking a blood sample to measure indicators of
inflammation, thrombosis. (hs-CRP (mg/dl), blood sample was used for gene
analysis, via DNA cleavage, in order to verify whether the above patients carry
gene polymorphisms associated with the production of CRP.
Results: the sample of the study were 164 individuals with an average age of
67,16 years. 39 of these were women (23.8 percent) and 125 men (67.2%). 22.5%
was up to 60 years, 68,9% 61-80 years and 8.6% > 81 years. The statistical
analysis shows that the people who are homozygous (GG) show lower values of CRP
compared with the heterozygous (AG) and the rare (A.A) with p< 0.001.
Specifically, the genotype (AA= rare) shows higher values CRP and differs
significantly from the statistics genotype (GG= result) and (AG= heterozygous),
p< 0.001, respectively. As regards the development of coronary heart disease
found that is associated with the high prices of CRP , p< 0.001.Also, from the
statistical analysis found that people with unstable angina presented higher
values CRP with statistically significant difference p< 0.001.
Conclusion: Ηigh levels of CRP and the genotype (A.A) is associated positively
with the progression of coronary heart disease.
