Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεων
Library of the School of Health Sciences

2014-05-16

2014

Αγγελίδης Αντώνιος

Καθηγητής Λεκάκης Ιωάννης

Μετάγγιση αίματος σε σχέση με τα ερυθροκυτταρικά αντιγόνα στην καρδιοχειρουργική πράξη

Greek

Frequency of Red blood groups and Rhesus in patients undergoing an open heart surgery. The incidence of Red blood cell alloantibodies and their clinical implications

Over a ten year period (1/1/2002-31/12/2011) 17224 patients undergoing a heart
surgery at OCSC were evaluated preoperative regarding the frequency of their
ABO blood groups, the Rh type and identification of red blood cell
alloantibodies and their clinical implications. In the study the demographics
of patients were also included: 1343 were babies/children (753/590 >/+) and the
remaining were adults (11485/3942 >/+). For 454 patients the surgery was redo.
The frequency of ABO phenotypes were O: 41,22%, A:40,37 %, B: 13,10%, AB:5,31
%. The frequencies of Rh(D) positive was 89,53 % and Rh(D) negative was 10,47
%.
The incidence of alloantibodies was 1,6% whereas 2,13% had a positive
undetermined otherwise antibody screen.
Within the alloantibodies the higher incidence showed the anti-E (0,435%)
followed by anti-D(0,22%), anti-Lea(0,203%) and anti-Kell (0,197%).
In the immediate and up to 3 months post surgical period only one delayed
haemolytic transfusion reaction (DHTR) resulting from an anti-Jka antibody was
observed. This antibody was probably developed 32 years previously throughout
pregnancy and subsequently declined so it was undetectable during
pretransfusion assessment. Therefore, the main approach to prevent a haemolytic
transfusion reaction is pretransfusion testing for potential haemolytic
antibodies by using both the antibody screen and the major cross-match.

Erythrocyte antigens, Cardiovascular surgery, Transfusion

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0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1312658