Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2015-12-10

2015

Πρωτόπαπας Ελευθέριος

Κων/νος Νικ. Συρίγος, Περικλής Τόμος,Ανδριανή Χαρπίδου

Χειρουργική αντιμετώπιση των ασθενών με βρογχοκυψελιδικό καρκίνωμα (BAC). Αναδρομική καταγραφή και μελέτη

Greek

Surgical treatment of patients with Bronchioloalveolar carcinoma (BAC). A retrospective analysis

Objective:Bronchιoloalveolar (BAC) carcinoma of the lung is one adenocarcinoma
with unique clinical and radiological characteristics. The goal of this study
is the retrospective analysis of the BAC patients and the risk factors that
affects their survival after surgical treatment
Material: Forty (40) patients with intraoperative diagnosis of BAC were
enrolled in a single center trial. The patient population consisted of twenty
one men and nineteen women with a mean age of 62 years. Lung resection was
performed to all patients from 2007 to 2012.
Methods:In all the patients the diagnosis of BAC was established with
intra-operative pathologic examination. Lobectomy or limited resection with
hilar and mediastinal lymph node dissection was performed, followed by
postoperative pathologic examination. Both pathological diagnosis based on the
definition by WHO in 2004. Patients enrolled in this study have been followed
for 36 to 84 months.
Results: Most patients were female (52,5%), no smokers and stage I (21). The
45% of the tumors were the ‘pure’ lepidic type of BAC and only 8 patients had
lymph node metastases. Full resection was completed to all patients either with
lobectomy (n=29) or with segmental or with wedge resection. The mean overall
survival for all patient was 70 months(95% CI, 63.87-77.51). The 1-year
survival rate was 100% and the 5-year was 81,7%. Independent predictors for
overall survival were: lymph node metastasis(HR: 5.59,p 0.036), final
staging(ΙΑ,ΙΒ,ΙΙΑvsΙΙΒ,ΙΙΙΑ)(HR:5.17,p 0.045) and the BAC type. The 5-year
survival rate among the patients with mixed BAC (66%) was significantly worse
than that among the ‘pure’ BAC group(100%,p 0.017).
Conclusions: The occurrence of BAC is only 3-4% of all lung cancers, and still
exists a 10-15% of adenocarcinoma with mixed type characteristics. Surgical
resection is the only potentially curative treatment despite the surgical
method. Patients with BAC have a higher rate of long-term survival.

Βronchioloalveolar carcinoma, Surgical treatment, Survival, Prognostic factor

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Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1314501