Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2014-09-12

2014

Καλογερή Νικολέττα

Καθηγήτρια Π.Κορκολοπούλου, Επ.Καθηγήτρια Μ.Σιακαντάρη, Γ.Λεβίδου

MALT λεμφώματα γαστρεντερικού συστήματος, κλινικοπαθολογοανατομική προσέγγιση - νεότερα δεδομένα

Greek

The mucosa associated lymphoid tissues (MALT lymphomas) of the gastrointestinal
constitute relatively infrequently category B Non- Hodgkin granulomas of out
lymphatic type primary. Histologically resemble the marginal zone lymphomas and
are classified in low-grade of malignancy lymphomas. The most common
localization is the folds of stomach (41%) with average age of onset the 60
years. In the gastrointestinal tract in the same category we have the
Immunoproliferative small intestinal disease (IPSID) or Mediterranean abdominal
lymphoma or the alpha chain disease, which characterized by the abnormal
production of truncated immunoglobulin IgA. The IPSID usually involve young
male (onset 20-22 years) and occurring in developing countries. Causative and
pathogenic factors to MALT lymphomas of the gastrointestinal are the chronic
inflammations:
H. pylori for MALT stomach lymphomas
Campylobacter jejuni for MALT small intestine lymphomas
The cytogenetic is characterized mostly by 3 translocations:
t(1;14) (p22;q32) -> overexpression of BCL10
t (11;18) (q21;q21) -> overexpression ΑΡI2 – MALT1
t (14;18) (q32;q21) -> overexpression of MALT1
The overproduction of the above proteins leads to activation of NF-kB, molecule
with a central role, that inhibit the cell apoptosis.For the first time the
disease is faced a malignancy by granting combination of antibiotics and
constitutes treatment of 1st line to MALT lymphomas of the
gastrointestinal.Immune/chemotherapy follows, while surgical treatment is
selected at complications of the disease (hemorrhage – perforation). MALT
lymphomas of stomach have the best prognosis (5-year survival 90 – 95 %). Just
5-10% of the MALT lymphomas can progress to high malignancy. The slow
evolution, the persistent localized disease and the mild biological behavior,
precede a hopeful sign to the excellent management and prognosis of patients
with MALT lymphomas of gastrointestinal.

MALT lymphomas gastrointestinal, Helicobacter pylori, Immune-chemotherapy, Pathology, NF-kB

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https://pergamos.lib.uoa.gr/uoa/dl/object/1314987