ΠΜΣ Μονάδες Εντατικής Θεραπείας και Καρδιολογική Νοσηλευτική
Library of the School of Health Sciences

2016-11-25

2016

Kyriazopoulos konstantinos

Αναπληρωτής Καθηγητής Τσιούφης Κωνσταντίνος

Συσχέτιση παχυσαρκίας και καρδιαγγειακής νοσηρότητας σε υπερτασικούς ασθενείς

Association of obesity and cardiovascular morbidity in hypertensive patients

Objectives: Obesity is a well-established risk factor for cardiovascular disease. We investigate the risk of cardiovascular morbidity in relation to body weight ratios in hypertensive patients treated or untreated, normal weight to mildly obese and without a history of cardiovascular disease.
Methods: We followed 1630 patients with hypertension (51.6% men, 25.8 obese, 76.1% with uncontrolled hypertension), who visited the Hypertension Unit of 1st University Clinic of Hippocrateion Hospital for an average period 3.89±1.69 years. At baseline we recorded clinical data including Body Mass Index (BMI) and waist circumference, blood pressure clinic, and performed routine laboratory and ultrasound examination. The primary end point was defined as cardiovascular morbidity corresponding to complex coronary disease and stroke.
Results: Total recorded 54 cardiovascular compatible of which 41 corresponded to coronary heart disease diagnoses and 13 strokes. From the univariate Cox regression, a significant correlation with cardiovascular compatible only showed waist circumference (HR = 1.036, 95% CI 1.010-1.063, p=0.007). In Cox multiple regression model setting as independent variables BMI, Waist Circumference and other cardiovascular risk factors, waist circumference showed independent correlation with cardiovascular events (HR=1.048, 95% CI 1.002-1.095, p=0.042) while the BMI showed independent negative correlation ( HR=0.847, 95% CI, 0.736-0.975, p=0.021)
Conclusions: In hypertensive patients of normal weight to mildly obese most weight appears to be associated with a better prognosis in terms of cardiovascular morbidity, and abdominal obesity worse, at least when they are placed in the same pattern as other risk factors. The correct therapeutic approach to these patients should include the optimal antihypertensive treatment, appropriate healthy measures and physical activity.

Obesity, Hypertension, Cardiovascular morbidity

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0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1325378