Postgraduate Programme Biostatistics & Health Science Data
Library of the School of Health Sciences

2017-05-30

2016

Veneti Lamprini

Βασιλική-Αναστασία Σύψα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτα Τουλούμη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Παρασκευής, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Ανάλυση δεδομένων σοβαρών κρουσμάτων εργαστηριακά επιβεβαιωμένης γρίπης που νοσηλεύθηκαν σε ΜΕΘ στην Ελλάδα κατά τις περιόδους γρίπης 2011-2012, 2012-2013, 2013-2014.

Greek

Analysis of data of severe laboratory confirmed influenza cases admitted to ICU in Greece during the influenza seasons 2011-2012, 2012-2013, 2013-2014.

BACKGROUND:
In 2009 a severe influenza monitoring system (SIMS) was established in Greece. The aims of this analysis were to estimate: 1) incidence, case fatality rate (CFR) of severe influenza cases as well as laboratory-confirmed mortality, 2) factors associated with patient survival, and 3) influenza vaccination coverage among severe influenza cases, using SIMS data from three influenza seasons (2011-2012/2012-2013/2013-14).
METHODS:
SIMS involved reporting all laboratory-confirmed influenza cases admitted to ICUs and deaths (regardless admission) to the Hellenic Center for Disease Control and Prevention. Each case was followed up daily, with a structured questionnaire, until discharge. Multiple logistic regression was used to assess factors independently associated with risk of death during admission.
RESULTS:
Overall, 578 severe cases and 268 deaths were recorded, of which 245 occurred in ICU. In 2013-14, incidence of severe influenza and mortality rate were 3-fold (3/100,000 population; 1.4 deaths/100,000 population, respectively) compared to 2011-12 and 2012-13 (1-1.2/100,000 population; 0.45-0.5 deaths/100,000 population). CFR were comparable in all three seasons (41%-42%). The risk of death (OR [95% CI]) was higher for patients with chronic kidney/hepatic disorder (3.0 [1.6-5.6]) and immunosuppression (1.9 [1.2-3.1]) vs. those without these conditions. Patients with ARDS (2.6 [1.7-4.0]), shock (5.1 [2.8-9.2]) and acute kidney failure (2.2 [1.2-3.9]) during ICU admission had higher risk of death. From 80% of cases with known vaccination status, 79% belonged to high risk groups and from those 15% were immunized.
CONCLUSIONS:
Incidence of severe influenza and influenza mortality increased during 2013-14 compared to the previous seasons. This increase may be associated with the circulation of A(H1N1pdm09). CFR was high in all seasons. Greek public health authorities should reinforce immunization campaigns to increase influenza vaccination uptake, targeting high risk groups.

Statistics

Medicine
Environment and public health

Influenza, Severe influenza, Vaccination, Mortality, Fatality, ICU, Hospitalized, Greece, Influenza seasons

No

0

Yes

48

119

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/1519608