Supervisors info:
Θεόδωρος Παπαϊωάννου, Αναπλ. Καθηγητής, Ιατρική, ΕΚΠΑ
Ελένη Κυριτση, Καθηγήτρια, Νοσηλευτική, ΕΚΠΑ
Τούσουλης Δημήτριος, Καθηγητής, Ιατρική, ΕΚΠΑ
Summary:
Introduction: Psychiatric patients are at increased risk of cardiovascular disease and other illnesses due to higher prevalence and inadequate attention to modifiable risk factors.
Aim: The aim of this study was to investigate the incidence of cardiovascular events in patients undergoing antipsychotic therapy.
Methods: The study sample consisted of 120 mentally ill patients who have been hospitalized or are still hospitalized at the Psychiatric Hospital of Attica. The data were collected from patients' envelopes from May 2017 to December 2018. All statistical analyzes were performed with the SPSS-22 statistical package and the statistical test t-test, Anova, x2-test and Pearson correlation
Results: The study included 120 psychiatric patients. The age of onset of psychiatric disorder at 75.8% was under the age of 30 years. A co-existing disease of 77.5% occurred after the onset of the mental disorder. After initiating antipsychotic treatment, 77.8% of the sample became obese. Individuals who received antidepressant medication showed an increase in HDL cholesterol, triglycerides, total cholesterol, systolic blood pressure, BMI (p <0.001) and blood sugar (p = 0.023). In the case of atypical antipsychotic medicinal products, in particular those taking olanzapine exhibit increased cholesterol, total triglycerides, total cholesterol (p<0.001), systolic blood pressure (p = 0.009), BMI increase (p <0.001) of blood sugar, (p = 0.045). Individuals taking conventional antipsychotic treatment as a whole received butyrophenone showed an increase in total cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, BMI and blood sugar (p <0.001) respectively, and a decrease in HDL cholesterol p = 0.001).
Conclusions: In the present study, the use of antipsychotic drugs was not responsible for the occurrence of acute coronary syndrome and cardiac events, however increased risk factors for coronary artery disease such as dyslipidemia, obesity, hypertension, and blood sugar were found
Keywords:
Antipsychotic drugs, Schizophrenia, Acute coronary syndrome, Cardiac events, Antidepressant drugs
