ΠΜΣ Μεταβολικά Νοσήματα των Οστών
Library of the School of Health Sciences

2018-07-18

2018

Evangelopoulos Dimitrios-Stergios

Κασσή Ευανθία, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Λυρίτης Γεώργιος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ
Τριανταφυλλόπουλος Ιωάννης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ

Ο ρόλος των οιστρογόνων στον ανδρικό σκελετό

Greek

Estrogens' impact on male skeleton

Estrogens are steroids with eighteen (18) carbon atoms. They are derived from estran and are chemically characterized by the presence of a hydroxyliated aromatic ring on carbon 3 (C3), providing them their phenolic properties. The main mechanism through which these hormones exert their effects is the interaction of the ligand with the receptor in the target tissue. The estrogen receptor (ER) belongs to the broader family of nuclear receptors.
Estrogens increase osteoblastic activity by suppressing the action of osteoclasts through interleukins and cause acceleration of longitudinal bone growth as well as early occlusion of long-term epiphyses. It is also essential to involve these hormones in the bone reconstruction process by their effect on the balance between osteoblasts and osteoclasts. Estrogen deficiency leads to prolonged osteoclastic action resulting in prolonged absorption phase duration and bone destruction size.
In addition to their direct anabolic action in the bone framework, estrogen receptors also exert regulatory activity through their interfacing with other pathways such as that of NF-kb and MAPK kinases, RANK / RANKL / OPG, Ca ++ / calmodulin and Wnt pathway.
New bibliographic data suggests that serum osteocalcin levels are significantly reduced in hypogonadal men, which confirms the significant effect of sexual steroids on maintaining bone formation in normal men. Since both estrogen and testosterone are as effective in preventing this acute reduction in serum osteocalcin levels, the findings suggest an important role for both sex steroids in maintaining bone formation in normal men. In contrast, changes in PINP levels, which reflect changes in the multiple stages of osteoblast development, indicate that it is primarily the estrogen that regulates this process. As for the rate of loss, an acute reduction in bone formation (within three weeks) following estrogen deprivation has been observed, a phenomenon similar to the acute increase in bone formation observed in other studies following parenteral E2 administration in postmenopausal women.

Health Sciences

Estrogen receptor, NF-KB, RANK/RANKL/OPG, Cross-talk, Male osteoporosis

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https://pergamos.lib.uoa.gr/uoa/dl/object/2778843