Κατεύθυνση Κλινική Νοσηλευτική: Ογκολογική Νοσηλευτική - Ανακουφιστική Φροντίδα
Library of the School of Health Sciences

2018-09-19

2018

Stylianou Christos

Πατηράκη Ελισάβετ, Καθηγήτρια, Νοσηλευτική, ΕΚΠΑ
Σταματάκης Αντώνιος, Αναπληρωτής Καθηγητής, Νοσηλευτική, ΕΚΠΑ
Κατσαραγάκης Στυλιανός, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ

Σχέση διατροφικής καθοδήγησης, επιπέδων ωκυτοκίνης και ανορεξίας ασθενών με καρκίνο που λαμβάνουν πλατίνα: πιλοτική μελέτη

Greek

Relationship of dietary counceling, oxytocin and anorexia in cancer patients receiving cisplatin: pilot study

Introduction-Background: Anorexia due to cisplatin has been associated with lower survival, reduced performance status, poor quality of life and decreased response to treatment. Cisplatin triggers the secretion of oxytocin, which has an anorectic effect and is involved in saturation signaling.
Aim: Exploring the effect of dietary counseling on oxytocin levels and anorexia in cancer patients receiving cisplatin.
Methodology: A two-periods intervention pilot study was conducted in a day-care oncology clinic for seven months. The sample was male patients with solid tumors treated with cisplatin. The patients were divided into the intervention group and the control group and then evaluated by a nurse based on the Scored Patient-Generated Subjective Global Assessment (PG-SGA) tool and a blood sampling for the measurement of oxytocin values prior to cisplatin. In addition, the intervention team received targeted nursing training based on the National Cancer Institute Eating Hints: Before, During and After Cancer Treatment. After receiving cisplatin and post-instillation, a new blood sampling was performed in all study patients. In the second period of the study a nursing nutritional assessment was performed using PG-SGA and a blood sampling for the measurement of oxytocin values prior to cisplatin in all patients.
Results: Of the 27 patients, 13 were assigned to the intervention group and 14 in the control group, with an average age of 53.6±9.4 and 53.4±9.2 years old, respectively. Compared to the control group, the intervention group had increase weight (53.8%) and food intake (46.2%) and decreased anorexia (23%). In the intervention group there was a statistically significant reduction in the PG-SGA score (p=0.002) from first (9.46) to the second period (6.8±3.8), while in the control group the score did not show statistically significant change (8±5 vs 14±5,8, p=0,426). The oxytocin values did not differed statistically between the two groups before receiving chemotherapy in the first (p=0.107) and the second phase (p=0.455). However, they were statistically significant higher (OR=26,440, 95% CI: 4,737-48,142, p=0,019) in the control group compared to intervention group after receiving cisplatin and hydration. Anorexia was not correlated statistically significant (p>0.05) with oxytocin values in the first and the second phase.
Conclusions: Our findings highlight the anorexia problem in patients receiving cisplatin and emphasize the importance of nursing nutritional counseling that contributes to weight and food intake increase, reducing anorexia and oxytocin values, improving the sense of safety and providing quality care with the least cost.

Health Sciences

Nursing Nutritional Counseling, Cancer, Cisplatin, Anorexia, Oxytocin

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https://pergamos.lib.uoa.gr/uoa/dl/object/2791105