ΠΜΣ Σακχαρώδης Διαβήτης και Παχυσαρκία
Library of the School of Health Sciences

2018-10-19

2018

Roussou Maria

Νικόλαος Τεντολούρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ασημίνα Μητράκου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κίμων Σταματελόπουλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Λιπώδες Ήπαρ-Συσχέτιση των δεικτών του λιπώδους ήπατος με την αθηρωμάτωση και την πρόγνωση των αρρώστων με στεφανιαία νόσο

English

Fatty liver disease

Background: Non-alcoholic fatty liver disease (NAFLD) correlates with high risk of cardiovascular incidents. Since first clinical presentation of CAD in more than 50% of patients is acute myocardial infarction and/or sudden death, early detection strategies are imperative.
Aim: In patients at high risk for cardiovascular events we examined whether non-invasive fatty liver indices could detect coronary and/or peripheral atherosclerosis extent and predict adverse outcome.
Methods: In 229 consecutive participants who were referred to our department for elective angiography for suspected coronary disease, peripheral vascular parameters were measured before cardiac catheterization. All patients were followed for cardiac death and/or myocardial infarction for 41± 1.2 months. Hepatic steatosis index (HSI), fatty liver index (FLI) platelets ratio index (APRI) and fibrosis-4 index (FIB-4) were calculated at the same time. Also, Pulse Wave Velocity, IMT common carotid, IMT carotid bulb, IMT combined, Flow Mediated Dilation and death by Myocardial Infraction were recorded
Results: The mean age was 63 ± 12 years and body mass index was 28.8 ± 4.97 kg/m2. Angiographically confirmed coronary disease was adjudicated in 60.9% of participants at baseline. FIB-4 was an independent determinant of increased pulse wave velocity (PWV), using multivariate analysis (p=0.048). APRI significantly correlated with carotid intima-media thickness (IMT) (p=0.013). Moreover, the APRI was associated with increased incidence of death from myocardial infarction (odds ratio=0.1, p=0.043).Conclusions: Non-invasively acquired fatty liver indices, and particularly APRI and FIB-4, are associated with coincident peripheral arterial damage as well as with adverse cardiac outcome in a population at high cardiovascular risk. Further investigation is warranted to clarify the clinical value of APRI and FIB-4 as a possible biomarker of cardiovascular risk.
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Health Sciences

Fatty liver disease, Cardiovascular Disease, Diabetes Mellitus, Atherosclerosis, Outcome

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https://pergamos.lib.uoa.gr/uoa/dl/object/2812518