Unit:
Κατεύθυνση Κοινωνικές και Ανθρωπιστικές ΣπουδέςLibrary of the School of Physical Education and Sport Science
Author:
Dagli Pagotto Fotini
Supervisors info:
Ζαχαρόγιαννης Ηλίας, Επίκουρος Καθηγητής, τομέας Κλασσικού Αθλητισμού, Σχολή Επιστήμης Φυσικής Αγωγής και Αθλητισμού. Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Μαριδάκη Μαρία, Αναπληρώτρια Καθηγήτρια, τομέας Αθλητιατρικής και Βιολογίας της Άσκησης, Σχολή Επιστήμης Φυσικής Αγωγής και Αθλητισμού. Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Παραδείσης Γιώργος, Αναπληρωτής Καθηγητής, τομέας Κλασσικού Αθλητισμού, Σχολή Επιστήμης Φυσικής Αγωγής και Αθλητισμού. Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Original Title:
Επίδραση της Άμεσης Χορήγησης Ακεταμινοφαίνης στην Απόδοση στην Αντοχή
Translated title:
Effect of Acute Acetaminophen Injestion on Running Endurance Performance
Summary:
Acetaminophen (ACT) is a potent nonopioid analgesic, fever reducer and cyclooxygenase (COX) inhibitor, within the central nervous system, drug. ACT clearly inhibits the production of prostaglandins (PG) which sensitizes and stimulates type II and IV afferents. It has been shown that ACT administration relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before it is felt. Therefore, ACT may improve performance through the reduction of pain for a given work rate by enabling participants to exercise closer to a true physiological limit. The aim of this study was to establish whether acetaminophen improves performance of self-paced exercise through the reduction of perceived pain. For that purpose, twenty recreationally active runners performed, an incremental test to determine VO2max. Participants completed a familiarisation test (4 days apart) of a 3 km time-trial (TT) treadmill run. On separate days the participants completed two experimental self-paced 3 km time-trial runs (7 days apart) on a treadmill beginning their effort on a 90%vVO2max velocity. During the experimental trials participants ingested either 1.5 g acetaminophen (ACT) or placebo (PLA) in a double blind, randomized, crossover design. The results showed that mean 3 km performance time was lower (p<0.05) after ACT (733.7 ± 92.86 s) compared with PLA (747.8 ± 95.9 s). ACT administration induced a mean 2% improvement in 3 km running performance. In conclusion, the present study shows that ACT administration improves running endurance performance through increased pain threshold. ACT ingestion lowered discomfort, allowing the runners to exercise at a greater intensity for the same level of perceived pain and exertion. The results of the present study support the notion that exercise performance is partly regulated by pain perception.
Main subject category:
Health Sciences
Keywords:
acetaminophen, metabolic parameters, running performance, pain, endurance
Number of references:
123
