Unit:
ΠΜΣ Έρευνα στη Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Παπαδημητρίου Ειρήνη
Supervisors info:
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική, ΕΚΠΑ
Παναγιώτης Βλαχογιαννόπουλος, Καθηγητής, Ιατρική, ΕΚΠΑ
Νικόλαος Βλάχος, Καθηγητής, Ιατρική, ΕΚΠΑ
Original Title:
Επίδραση αντιφωσφολιπιδικών αντισωμάτων στην έκβαση των τεχνικών υποβοηθούμενης αναπαραγωγής. Συστηματική ανασκόπηση και μετα-αναλυση
Translated title:
Presence of antiphospholipid antibodies is associated with increased failure rates of assisted reproductive techniques: A systematic review and Meta-analysis
Summary:
Fifteen observational studies, which included healthy women of reproductive age without a diagnosis of antiphospholipid syndrome, were selected in this study to evaluate the association between the presence or absence of antiphospholipid antibodies and implantation outcome after in vitro fertilization and embryo transfer (IVF-ET). This meta-analysis compared the presence of antiphospholipid antibodies in women of reproductive age experiencing at least two implantation failures in IVF-ET and in controls (control 1: women who had a successful implantation after IVF-ET or control 2: women with at least one successful pregnancy from spontaneous conception or unselected healthy women with no history of IVF-ET).
Main outcomes were the presence of any type of antiphospholipid antibodies; anticardiolipin; anti-beta2 glycoprotein I; lupus anticoagulant; anti-phosphatidylserine; anti-phosphatidylcholine; anti-phosphatidylethano¬lamin or anti-phosphatidylinositol or anti-phosphatidyl-glycerol or anti-phosphatidic acid antibodies in association with implantation outcome after IVF-ET. Effects were reported as relative risks and their 95% confidence intervals (CIs).
The presence of any type of aPL antibodies and of only anticardiolipin antibodies is associated with a significant 3.44 and 5.11 relative risk for implantation failure after IVF-ET, respectively, as compared to women experiencing one successful IVF-ET. The presence of either anticardiolipin or lupus anticoagulant or anti-β-2GPI or anti-phosphatidylserine antibodies is associated with a significant 14.91, 4.57, 55.6 and 226.89 relative risk for implantation failure, respectively, as compared to women with at least one successful pregnancy from spontaneous conception or unselected healthy women with no history of IVF-ET.
The presence of antiphospholipid antibodies without the diagnosis of antiphospholipid syndrome was significantly higher among women with implantation failure after IVF-ET compared with either women with implantation success after IVF-ET or unselected healthy women with no history of IVF-ET.
Main subject category:
Health Sciences
Keywords:
Antiphospholipid, Implantaion , IVF
