Κατεύθυνση Βιοπληροφορική
Library of the School of Science

2018-11-02

2018

Pavlos Apostolos-Evgenios

Κωνσταντίνος Βοργιάς, Καθηγητής, Τμήμα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Παντελεήμων Μπάγκος, Αναπληρωτής Καθηγητής, Τμήμα Πληροφορικής με Εφαρμογές στη Βιοϊατρική, Πανεπιστήμιο Θεσσαλίας
Βασιλική Οικονομίδου, Επίκουρη Καθηγήτρια, Τμήμα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών

ΔΙΕΡΕΥΝΗΣΗ ΓΙΑ ΥΠΑΡΞΗ ΣΥΣΧΕΤΙΣΗΣ ΜΕΤΑΞΥ ΠΟΣΟΣΤΟΥ GC ΣΤΟ ΓΟΝΙΔΙΩΜΑ ΚΑΙ ΘΕΡΜΟΚΡΑΣΙΑΣ ΑΝΑΠΤΥΞΗΣ (GOT) ΣΤΑ ΒΑΚΤΗΡΙΑ

Greek

INVESTIGATION FOR CORRELATION EXISTENCE BETWEEN GC PERCENTAGE AND GROWTH TEMPERATURE (GOT) OF GENOME IN BACTERIA

In recent decades, one of the central issues of evolutionary genomics is to find adaptive strategies for the stabilization of nucleic acids under high temperatures (Basak and Ghosh 2005; Basak et al., 2010). All macromolecules, such as DNA and RNA, must be stable and functional at high growth temperatures. The hypothesis of thermal adaptation supports the positive correlation between the genome content of guanine and cytosine (G + C) and the Growth Optimal Temperature (GOT) of the organisms, because the G + C base pair has one above hydrogen bond with respect to the adenine-thymine pair (A + T), and is therefore more stable.
The prevailing view is that there is no universal generalization of the hypothesis of thermal adaptation to prokaryotic organisms. All studies carried out on this subject were "limited" in the sense that the number of species analyzed was relatively small with respect to all existing microorganisms.
The aim of this work is to try to see the problem more generally, and more specifically, in all available prokaryotic organisms, in order to investigate whether or not there is a correlation between GC% in the genome and growth temperature (GOT) of organisms by verifying or not the thermal adaptation assumption. In the case that such a correlation exists between these two parameters, we could claim that G + C content is an important factor in the development of bacteria at a specific temperature. If there is no correlation between the two variables, then we come to the prevailing view that there is no correlation between the G + C genome content and the optimal bacterial growth temperature, and possibly the factors related to the adaptation of prokaryotes organizations in different environments are different.

Science

Genome, Correlation, GC Percentage, Growth Optimal Temperature, Prokaryotic Organisms, Bacteria

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2817001