Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2018-12-27

2018

Theodoulou Danai

Γρηγόριος Στρατάκος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Κουλούρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Γκιόζος, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ

Καταγραφή ερωτηματολογίων ποιότητας ζωής σε ασθενείς με καρκίνο πνεύμονα που υποβάλλονται σε επεμβατική διάνοιξη κεντρικού αεραγωγού και διάρκεια βελτίωσης έως την πρώτη υποτροπή

Greek

Quality of Life after endobronchial intervention of malignant central airway obstruction and time until first relapse.

Background: Patients with malignant central airway obstruction (mCAO) may need endobronchial intervention to relieve their symptoms. Quality of life (QoL) has been closely linked with symptom intensity in lung cancer patients. It is therefore important to relieve respiratory distress and inform patients, especially those who receive palliative care, about the benefits of endobronchial intervention.
Aim: The objective of this single-center study was to assess prospectively the effect of therapeutic bronchoscopic interventions on quality of life, dyspnea, and relapse time in patients with mCAO.
Methods: Over a 18-month period, we enrolled 29 patients with symptomatic malignant central airway obstruction in order to re-establish airway patency. QoL and dyspnea were evaluated by the EORTC-C30 and EORTC-LC13 Questionnaire before the intervention, 1 week after and every following month until first relapse or death. In addition, data concerning demographic, clinical details and performance status were collected. Statistical analysis was performed for a 6month period.
Results: Overall, 44.8% of patients (n=13) had poor PS (≥3) and 51.7% (n=15) of patients were stage IV disease. QoL improved significantly from the first week up to the 6th month (p<0.05). Global Health Questionnaire improved from 29.6(SD=19.2) to 70.8 (SD=30.5) on week 24(p<0.05). Dyspnea accessed with EORTC-LC13 questionnaire decreased from 73.2 (SD=29.2) to 23.6 (SD=26) on week 24. Patients with PS ≥3 and those at stage IV had greater improvement. Benefits were seen independent of histology of malignancy or history of post-obstructive pneumonia. Mean time until first relapse was 21.2 weeks (SD=20.5) (n=6 patients) and time until death was 15.1weeks (SD=7.9) (n=16 patents). Patients treated with chemotherapy before the intervention and those with stenosis of trachea and left main bronchus had worse survival.
Conclusions: Interventional management of patients with mCAO results in sustained significant improvement of quality of life and shortness of breath and should be considered as essential component of multidisciplinary cancer care approach.

Health Sciences

Central Airway Obstruction, Interventional Bronchoscopy, Lung Cancer, Quality of Life

No

0

Yes

30

73

File access is restricted only to the intranet of UoA.

https://pergamos.lib.uoa.gr/uoa/dl/object/2838032