Unit:
Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και ΈρευναLibrary of the School of Health Sciences
Author:
Papachristidi Cleopatra
Supervisors info:
Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή ΕΚΠΑ, Επιβλέπων
Γρηγόριος Στρατάκος, Επίκουρος Καθηγητής, Ιατρική Σχολή ΕΚΠΑ
Αικατερίνη Δημάκου, Διδάκτωρ, Ιατρική Σχολή ΕΚΠΑ
Original Title:
Ποσοστό πλήρους εξαιρεσιμότητας τοπικά εκτεταμένου μη μικροκυτταρικού καρκίνου πνεύμονα μετά από εισαγωγική θεραπεία. Σύγκριση παθολογoανατομικής και προεγχειρητικής κλινικής υποσταδιοποίησης του μεσοθωρακίου.
Translated title:
Τhe percentage of successful excision of locally expanded non-small cell lung cancer after induction therapy. Comparison of the pathological and pre-operative substaging of mesothorax
Summary:
BACKGROUND
Lung cancer is the primary cause of death amongst cancer patients. Non-small cell lung cancer represents more than 80% of lung cancer, and approximately one fourth of them are diagnosed at stage III.
Surgery for stage III is considered to be ineffective by itself and does not increase survival. In order to increase survival, chemotherapy is combined with or without radiation treatment before and/ or after surgery.
OBJECTIVES
The objectives of this study is to calculate the percentage of successful excision of locally expanded non-small cell lung cancer after induction therapy, as well as comparing the pathological and pre-surgical clinical cancer sub staging.
PATIENTS, MATERIALS AND METHODS
We screened the patient archive of the Oncology Unit of Sotiria Hospital and we identified 25 patients with non-small cell lung cancer stage III as an initial diagnosis, who received induction therapy followed by surgical excision. The following nine parameters were followed: initial clinical staging, type and duration of induction therapy, staging of cancer after induction therapy, type of surgical excision, pathologic staging, additional therapy, clinical progress and the duration of observation of patients free of relapse.
RESULTS
Complete resection was achieved in nine out of 25 patients (36%). Clinical substaging of mesothorax was performed in 17 out of 22 patients (77.27%) and pathologic substaging in 16 out of 22 patients (72.72%). Comparison of the pathological (pN2) and pre-operative substaging of mesothorax (cN2) demonstrated false positive cN2 disease in two out of five patients. True positive cN2 disease was confirmed in three out of five patients. False negative cN2 disease was found in three out of 20 patients. True negative cN2 disease was proved histologically in 17 out of 20 patients.
Main subject category:
Health Sciences
Keywords:
Locally advanced non-small cell lung cancer, Induction therapy, Substaging of mesothorax, Adjuvant therapy,
File:
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Ποσοστό πλήρους εξαιρεσιμότητας τοπικά εκτεταμένου μη μικροκυτταρικού καρκίνου πνεύμονα μετά από εισαγωγική θεραπεία. Σύγκριση παθολογoανατομικής και προεγχειρητικής κλινικής υποσταδιοποίησης του μεσοθωρακίου..pdf
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File access is restricted only to the intranet of UoA.
