Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2018-12-19

2018

Eleftheriou Konstantinos

Καλομενίδης Ιωάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μπακάκος Πέτρος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πουλάκου Γαρυφαλλία, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Επίπτωση, διάγνωση και προγνωστική σημασία της προσβολής του υπεζωκότα σε ασθενείς με Καρκίνο Πνεύμονα

Greek

Incidence, diagnosis and prognostic significance of malignant pleural ifiltration in patients with Lung Cancer

Lung Cancer is a very serious disease with high rates of incidence and morbidity, and based on histological classification, it is categorized as Small Cell and Non-Small Cell lung carcinoma, which is divided into adenocarcinoma, squamous and large cell carcinoma. As for the staging of NSCLC, the TNM system has prevailed based on the latest 8th revision, while for the SCLC, the simpler and more practical classification is used in limited and extented disease. Malignant pleural infiltration, either in the form of abnormal nodular thickening of the pleura or in the form of a malignant pleural effusion, is associated with poor prognosis and is therefore classified at an advanced stage. The diagnosis is made either by positive cytological examination of the pleural fluid, positive pleural biopsy or finally based on clinical / imaging criteria when histocytological confirmation is not feasible or necessary.
This study investigates the incidence, diagnosis and prognostic significance of malignant pleural infiltration in patients with lung cancer. This is a retrospective review of 356 lung cancer patients enrolled in the Oncology Unit of the 3rd University Internal Medicine Clinic of the National Kapodistrian University of Athens in the period 2016-2017 Of these patients, 181 were at an advanced stage, while 74 of them had an initial diagnosis of a malignant pleural effusion. Malignant pleural effusions were more common right than left, while around 20% were large in size. There appeared to be a correlation with adenocarcinoma as a higher incidence was observed in patients with malignant effusions (46%), while increased PFS was found in patients with SCLC. There was also a better response to Targeted Therapy, as well as a tendency for better response of the pleura with respect to the chest or the rest of the body. Finally, although the results with regard to the overall outcome are contradictory, there is evidence that the presence of a malignant pleural effusion may affect survival rates.

Health Sciences

Pleura, Malignant pleural effusion, Lung cancer

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/2838263