The effect of different embryo transfer techniques on in vitro fertilization (IVF) results

Doctoral Dissertation uoadl:2867693 98 Read counter

Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
Sigalos Georgios
Dissertation committee:
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Βλάχος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Κωνσταντίνος Πανουλής, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Παναγιώτης Βάκας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Λέων Αραβαντινός, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πανοσκάλτσης Θεόδωρος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελευθεριάδης Μακάριος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επίδραση διαφορετικών τεχνικών φόρτωσης του καθετήρα εμβρυομεταφοράς στα αποτελέσματα κύκλων εξωσωματικής γονιμοποίησης (IVF)
Translated title:
The effect of different embryo transfer techniques on in vitro fertilization (IVF) results
Over the last few years, many studies have focused on embryo selection methods, whereas little attention has been given to the standardization of the IVF and embryo transfer procedure. The volume of the culture medium transferred into the uterine cavity is a variable that has been suggested to affect the IVF outcome. The aim of this prospective randomized control trial was to evaluate if the use of two different volumes (20-25 μl VS 40-45 μl) of media used for embryo transfer affects the clinical outcomes in fresh in vitro fertilization cycles (IVF).
In 2016 a review of the literature was conducted to review the variables affecting the embryo transfer and to compare the existing embryo transfer techniques. In parallel, 236 patients were randomized in two groups i.e. ‘low volume group’ (n=118) and ‘high volume group’ (n=118) based on the volume used for the embryo transfer. The clinical pregnancy, implantation and ongoing pregnancy rates were compared between the two groups.
No statistically significant differences were observed in clinical pregnancy (46.8 vs 54.3 %, p=0.27), implantation (23.7 vs 27.8%, p=0.30) and ongoing pregnancy (33.3 vs 40.0%, p=0.31) rates between low and high volume group, respectively. Consequently, higher volume of culture medium to load the embryo into the catheter during embryo transfer does not influence the clinical outcome in fresh IVF cycles.
Main subject category:
Health Sciences
Embryo transfer techniques, In vitro fertlization, Embryology laboratory
Number of index pages:
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