Faculty of Medicine
Library of the School of Health Sciences

2019-04-19

2019

Tsotra Maria

Χρούσος Γεώργιος, Ομότιμος Καθηγητής, Ιατρική, ΕΚΠΑ
Παπαβασιλείου Αθανάσιος, Καθηγητής, Βιοχημεία, ΕΚΠΑ
Κωνσταντόπουλος Κωνσταντίνος, Καθηγητής, Ιατρική, ΕΚΠΑ
Παναγιωτίδης Παναγιώτης, Καθηγητής, Ιατρική, ΕΚΠΑ
Βασιλακόπουλος Π. Θεόδωρος, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Πιπέρη Χριστίνα, Αναπληρώτρια Καθηγήτρια, Βιοχημεία, ΕΚΠΑ
Μοσχοβή Μαρία, Επίκουρη Καθηγήτρια, Ιατρική, ΕΚΠΑ

Ο ρόλος των STAT μεταγραφικών παραγόντων στην οξεία λεμφοβλαστική λευχαιμία της παιδικής λευχαιμίας

Greek

Role of STAT transcript levels in pediatric acute lymphoblastic leukemia

We investigated the transcript levels of genes STAT1, STAT3, STAT5A and STAT5B in the diagnostic samples of childhood ALL patients and compared them to those of healthy controls in order to characterize STAT gene expression in childhood ALL. As compared to controls, ALL patients exhibit markedly decreased transcript levels in all four genes investigated. STAT1 and STAT3 are significantly correlated in ALL patients as opposed to controls (P < 0.0005). Patients with low transcript levels of STAT1 and STAT3 survive, regardless of minimal residual disease status and relapse. Lower transcript levels appear in association with higher survival rate in the ALL patients. The identification of aberrant expression profiles provides insight into the role of STAT genes in the development of childhood ALL and enables development of patient-tailored therapeutic approaches in cases of resistant disease.

Health Sciences

Pediatric Acute Lymphoblastic Leukemia, STAT1 transcript factor, STAT3 transcript factor, STAT5 transcript factor

No

0

Yes

144

119

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https://pergamos.lib.uoa.gr/uoa/dl/object/2867926