Τομέας Χειρουργικής
Library of the School of Health Sciences

2019-04-19

2019

Christou Alexandra

Γεώργιος Ζωγράφος, Καθηγητής, Ιατρική, ΕΚΠΑ
Κωνσταντίνος Κόντζογλου, Καθηγητής, Ιατρική, ΕΚΠΑ
Κωνσταντίνος Γ. Τούτουζας, Αναπληρωτής Καθηγητής, Ιατρική, ΕΚΠΑ
Φλώρα Ζαγουρή, Αναπληρώτρια Καθηγήτρια, Ιατρική, ΕΚΠΑ
Μιχαήλ Κοντός, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Βασίλειος Κουτουλίδης, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ
Νικόλαος Μιχαλόπουλος, Επίκουρος Καθηγητής, Ιατρική, ΕΚΠΑ

Η επίτευξη χειρουργικών ορίων στις μη ψηλαφητές μαστογραφικές αλλοιώσεις του τύπου των μικροαποτιτανώσεων με τη χρήση της ελάχιστα επεμβατικής τεχνικής λήψης ακέραιου ιστοτεμαχίου (BLES)

Greek

Effectiveness and predictive factors of breast lesion excision system (BLES) in complete removal of suspicious microcalcifications

Aim: to retrospectively assess the effectiveness of BLES in complete removal of suspicious microcalcifications
Methods and materials: between January 2014 and January 2016, 400 biopsies of suspicious microcalcifications performed in our department using the BLES stereotactic device. The mean age of our population was 58.5 years old (range 39-78 years). 20 mm probe was used for all biopsies. The pathology results of BLES specimens were assessed and compared with the final surgical results. The initial mammographic size, the distance of the lesion from the tissue specimen, the grade, molecular type and the presence of comedo necrosis were statistically analysed as possible predictive factors. ROC analysis was used to determine effective cut off points for each predictive factors.
Results: 90/400 (22.5%) biopsies were cancers and 38/400 were atypical lesions (9.5%). DCIS was found in 72/90 (80%). The mean size of the microcalcifications was 15.38 mm (st. dev.= 13.579 mm, range 3-78 mm). Complete removal was achieved in 31/90 cases (34.4%) and in 23/29 atypical lesions that underwent surgery (76.3%). Predictive factors were the initial mammographic size (p<0.001), the distance of the lesion from the specimen margins (p<0.001), the presence of comedo necrosis (p=0.014) and the grade (p=0.021). At a cut off size of 14 mm , ROC analysis revieled 100% sensitivity (AUC:0.892) and removal rate of 57.4%. At a cut off distance of 0.75 mm free disease margins, ROC analysis showed that the specificity is 96,6% (AUC:0,816). The underestimation rate was 15.5%.
Conclusion: BLES is a highly accurate biopsy technique with potential use as therapeutic tool in the management of selected cases of suspicious clusters of microcalcifications.

Health Sciences

Breast cancer, Stereotactic biopsy, Excision, Microcalcifications, BLES

No

0

Yes

373

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https://pergamos.lib.uoa.gr/uoa/dl/object/2868064