Unit:
Κατεύθυνση ΒιοπληροφορικήLibrary of the School of Science
Supervisors info:
Βασιλική Οικονομίδου, Επίκουρη Καθηγήτρια, Τομέας Βιολογίας Κυττάρου και Βιοφυσικής, Τμήμα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο
Σταύρος Χαμόδρακας, Ομότιμος Καθηγητής, Τομέας Βιολογίας Κυττάρου και Βιοφυσικής, Τμήμα Βιολογίας, Εθνικό και Καποδιστριακό Πανεπιστήμιο
Ευαγγελία Χρυσίνα, Ερευνήτρια Β’, Ινστιτούτο Βιολογίας, Φαρμακευτικής Χημείας και Βιοτεχνολογίας, Εθνικό Ίδρυμα Ερευνών
Original Title:
Δημιουργία βάσης δεδομένων για ασθένειες που σχετίζονται με την εναπόθεση αμυλοειδών ινιδίων
Translated title:
Creation of a database for diseases associated with amyloid deposition
Summary:
Amyloid fibrils are formed when soluble proteins self-assemble into insoluble, highly ordered aggregates. “Amyloidosis” is a term used to describe a broad class of diseases caused by the deposition of amyloid fibrils in various human organs and tissues. Impressively, amyloid fibril deposition has been also recorded as the complication in a number of pathological conditions, including well-known neurodegenerative or endocrine diseases. Moreover, amyloidosis has been recorded as a rare complication in many other pathological conditions.
In an effort to gain an overview of these diseases a literature review was performed, aiming to create a comprehensive repository for amyloidoses and other clinical conditions related to amyloid deposition. In this thesis, we present AmyCo, a database of amyloidoses and diseases related to amyloid deposition. Currently, it contains information about 75 diseases, classified based on their association with amyloid deposition in 2 major categories, namely “Amyloidoses” and “Clinical conditions associated with amyloidosis”. Each database entry is annotated with the amyloidogenic precursor protein (causative protein), other components of amyloid deposits (co-deposited proteins) and affected tissues or organs. Database entries are also supplemented with appropriate detailed annotation and are referenced to ICD-10, MeSH, OMIM, PubMed, AmyPro and UniProtKB databases. AmyCo is the first attempt to collect the diverse group of amyloidoses into an updated and freely available database.
Main subject category:
Science
Keywords:
amyloid fibrils, amyloidosis, database, amyloid deposition
Number of references:
228
